[Association of sudden sensorineural hearing loss and its prognosis with the brain white matter hyperintensity]

Objective:To explore the relationship between white matter hyperintensity（WMH） and sudden sensorineural hearing loss（SSHL） and evaluate the influence of WMH on the prognosis of SSHL. Methods:Fifty hospitalized unilateral SSHL patients and 50 age and gender matched routine physical examination individuals without SSHL history from June 2019 to June 2020 were included for a case-control study. All included subjects underwent 3.0 Tesla cranial magnetic resonance examination, and the Fazekas scale was applied to evaluate periventricular white matter hyperintense（PVWMH） and deep white matter hyperintense（DWMH）. Fazekas score and distribution proportions of Fazekas score was compared between SSHL and control. Ordered logistic regression was used to study the relationship between prognosis of SSHL and WMH. Results:The Fazekas score of WMH in SSHL group was significantly higher than that of control group（PVWMH: P=0.004, DWMH: P=0.010）; There was a significant difference in the distribution proportions of Fazekas scores between SSHL and control（PVWMH: P=0.036, DWMH: P=0.047）; The results of ordered logistic regression showed that patients without WMH（Fazekas=0） is an independent predictor of good prognosis in SSHL（P=0.025, OR=12.779）. Conclusion:The prevalence of WMH in SSHL patients was higher than that of control. SSHL patients without WMH has a better prognosis than those with WMH.