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Hexyl-nicotinate-induced vasodilation in normal human skin
Dermatologica
|January 1, 1987
Summary
Hexyl nicotinate lotion effectively increases skin blood flow, acting as a vasodilator. This effect can occur even with minimal visible skin redness, indicating its potency.
Area of Science:
- Dermatology
- Pharmacology
- Physiology
Background:
- Hexyl nicotinate is a topical agent with potential vasodilatory properties.
- Understanding its effect on skin microcirculation is crucial for dermatological applications.
Purpose of the Study:
- To evaluate the dose-related effects of topical hexyl nicotinate on skin erythema and blood flow.
- To determine the efficacy of hexyl nicotinate as a cutaneous vasodilator in healthy volunteers.
Main Methods:
- Ten healthy volunteers received topical application of hexyl nicotinate lotion.
- Erythematous responses were assessed visually.
- Skin blood flow was quantified using a laser Doppler flow meter (Pf2 Perimed, Sweden).
Main Results:
- Both erythema and increased skin blood cell flux showed a dose-dependent relationship with hexyl nicotinate.
- Significant increases in blood flow were observed in some subjects with minimal visible erythema.
- Hexyl nicotinate demonstrated dose-related cutaneous vasodilation.
Conclusions:
- Hexyl nicotinate is an effective cutaneous vasodilator.
- Its vasodilatory effect can be pronounced even when minimal erythema is present.
- This suggests potential therapeutic applications in conditions requiring enhanced skin blood flow.