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Quality Assurance01:19

Quality Assurance

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Quality assurance is the overarching term used to describe the activities employed to ensure the proper performance of a system. These activities can be classified into three categories: quality control, quality assessment, and internal corrective measures. Typically, these activities work cyclically: quality control is performed before and during the analysis, while quality assessment occurs during and after the investigation. Internal corrective measures are implemented based on the findings...
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ER is the primary site for the maturation and folding of soluble and transmembrane secretory proteins. The calnexin cycle is a specific chaperone system that folds and assesses the confirmation of N-glycosylated proteins before they can exit the ER lumen. The primary players of this quality check pipeline are the lectins, ER-resident chaperones, and a glucosyl transferase enzyme. In case the calnexin system in the lumen fails to salvage a misfolded protein, it is transported to the cytoplasm...
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Quality Control01:05

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Quality control is one of the three cyclical quality assurance activities that help keep a system under statistical control. Typical quality control activities include creating quality control charts, conducting proficiency testing, and documenting and archiving results.
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Today, scientists agree that good research is ethical in nature and is guided by a basic respect for human dignity and safety. However, this has not always been the case. Modern researchers must demonstrate that the research they perform is ethically sound.
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Development of Analytical Methods01:21

Development of Analytical Methods

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An analytical methodology can be divided into four sequential steps: technique, method, procedure, and protocol. A technique is a scientific principle that rationalizes a specific phenomenon through chemical measurements. Adapting a technique for analyzing a sample of interest is termed a method. The procedure outlines the directions for performing the analysis via an analytical method. The protocol is the detailed guidelines on the procedure, which should be strictly followed to obtain the...
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Quality of Water01:19

Quality of Water

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In concrete preparation, the quality of water is paramount as it affects the strength and durability of the concrete. Potable water is usually preferred; however, it must not have excessive sodium or potassium to prevent compromising the concrete's integrity. Water quality is typically evaluated based on impurities such as dissolved solids, chlorides, and sulfates, and its pH value is ideally between 6 and 8. Even slightly acidic natural water may be acceptable unless it contains harmful...
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Proper Care and Cleaning of the Microscope
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Assessing and Improving Research Quality in Core Facilities.

Isabelle C Kos-Braun1, Björn Gerlach2, Claudia Pitzer1

  • 1Interdisciplinary Neurobehavioral Core, Heidelberg University 69120 Heidelberg Germany.

Journal of Biomolecular Techniques : JBT
|July 15, 2022
PubMed
Summary
This summary is machine-generated.

Core facilities enhance research efficiency but require robust data quality. A new interactive website helps these shared scientific resources improve experimental rigor and reproducibility.

Keywords:
benchmarkingbiological science disciplinescommunicationdata managementreproducibility of resultsself-testing

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Area of Science:

  • Biotechnology
  • Scientific Research Infrastructure

Background:

  • Core facilities provide access to specialized technologies, increasing research efficiency and data generation.
  • Shared experimental workflows in core facilities present challenges in maintaining data rigor and reproducibility.
  • Effective communication, trust, and accountability are crucial for data integrity in shared research environments.

Purpose of the Study:

  • To present an interactive website designed to support core facilities.
  • To offer tools for assessing, improving, and ensuring research quality within core facilities.

Main Methods:

  • Development of an interactive website tailored for core facility needs.
  • Integration of tools for quality assessment and improvement.

Main Results:

  • The website provides a centralized platform for managing and enhancing research quality.
  • Tools facilitate better communication and accountability between facility staff and users.

Conclusions:

  • The developed website offers a practical solution for core facilities to uphold high standards of research quality.
  • Implementing this tool can lead to improved data rigor and reproducibility in shared experimental settings.