Familial occurrence of typhoid acute glomerulonephritis

Three cases of typhoid nephritis occurring in a single family are reported. A clinical similarity to poststreptococcal nephritis was noted, although no hypocomplementemia was observed. The same phage type occurred in other patients who did not exhibit nephritis. The possibility of a host factor was therefore considered to be involved, although no HLA haploid-type link was found in the patients. These cases illustrate that in certain geographical areas the possibility of typhoid fever should be considered in patients with nephritis and concomitant fever.