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A comprehensive network map of IL-17A signaling pathway
D A B Rex1, Shobha Dagamajalu2, Mahesh Manjunath Gouda3
1Centre for Integrative Omics Data Science, Yenepoya (Deemed to be University), Mangalore, Karnataka, 575018, India. rexprem@yenepoya.edu.in.
Journal of Cell Communication and Signaling
|July 15, 2022
Summary
This study presents a comprehensive pathway map of Interleukin-17A/Interleukin-17 Receptor A signaling. The resource details 114 proteins and 68 reactions, aiding research into autoimmune diseases and cancer.
Area of Science:
- Immunology
- Molecular Biology
- Systems Biology
Background:
- Interleukin-17A (IL-17A) is a key cytokine produced by Gamma delta (γδ) T cells and T helper 17 (Th17) cells.
- Aberrant IL-17A signaling is implicated in autoimmune diseases like idiopathic pulmonary fibrosis, acute lung injury, chronic airway diseases, and cancer.
Purpose of the Study:
- To develop a detailed pathway resource for IL-17A/Interleukin-17 Receptor A (IL-17RA) signaling events.
- To integrate curated literature data into a comprehensive signaling pathway map.
Main Methods:
- Manual curation of literature data using NetPath criteria.
- Development of an integrated pathway reaction map detailing proteins and reactions involved in IL-17A/IL-17RA signaling.
Main Results:
- The study describes an integrated pathway map of IL-17A/IL-17RA signaling, comprising 114 proteins and 68 reactions.
- Detailed information on signaling events including activation/inhibition, catalysis, molecular association, gene regulation, protein expression, and translocation was cataloged.
- The pathway map data is publicly accessible via the WikiPathways Database (WP5242).
Conclusions:
- The developed IL-17A/IL-17RA signaling pathway map provides a valuable resource for understanding its role in disease pathogenesis.
- This integrated map facilitates further research into the complex molecular mechanisms underlying IL-17A-mediated biological processes.
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