Changes of Pulmonary Microhemodynamics in Experimental Pulmonary Thromboembolism after Pretreatment with K-Channel...

Changes in pulmonary microhemodynamics in response to pulmonary embolism under conditions of activation of K_ATP channels with nicorandil, Kv channels with dapagliflozin, and BK_Ca channels with Evans blue were studied on isolated rabbit lungs. Under conditions of activation of K_ATP and BK_Ca channels, the constrictor reactions of the pulmonary arterial vessels during embolization of the pulmonary artery were less pronounced than in the control. Activation of BK_Ca channels reduced constrictor reactions of the pulmonary venous vessels, while activation of K_ATP and Kv channels eliminates them. The shifts of the capillary filtration coefficient are determined to a greater extent by the pre-/postcapillary resistance ratio, than by changes of the endothelial permeability. Pretreatment with dapagliflozin led to a decrease in the capillary filtration coefficient. It was established, that nimesulide exhibits properties of a BK_Ca-channel activator.