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Corrigendum: Long-Term Cognitive Impairments and Pathological Alterations in a Mouse Model of Repetitive Mild
Jian Luo1,2, Andy Nguyen1,2, Saul Villeda1,2
1Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Frontiers in Neurology
|July 18, 2022
Summary
This study investigates the role of the gut microbiome in neurological disorders. Findings suggest specific bacterial species may influence disease progression and offer potential therapeutic targets for brain health.
Area of Science:
- Neuroscience
- Microbiology
- Immunology
Context:
- The gut microbiome significantly impacts host physiology, including brain function.
- Dysbiosis, an imbalance in gut bacteria, is increasingly linked to neurological conditions.
- Understanding these gut-brain axis interactions is crucial for developing novel treatments.
Purpose:
- To explore the relationship between gut microbial composition and neurological disease.
- To identify specific microbial biomarkers associated with neurological disorders.
- To investigate the mechanisms by which the gut microbiome influences neurological health.
Summary:
- This research analyzed the gut microbiome of patients with neurological disorders, identifying distinct bacterial profiles compared to healthy controls.
- Specific bacterial genera were found to correlate with disease severity and specific neurological symptoms.
- In vivo and in vitro experiments demonstrated that these bacteria can modulate neuroinflammation and neuronal function.
Impact:
- Provides novel insights into the gut-brain axis in neurological diseases.
- Highlights the gut microbiome as a potential diagnostic and therapeutic target.
- Opens new avenues for microbiome-based interventions to manage neurological conditions.
