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Scientists' Views on Scientific Self-Governance for Human Genome Editing Research.

R Jean Cadigan¹, Margaret Waltz¹, Gail E Henderson¹

¹Department of Social Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.

Human Gene Therapy

|July 19, 2022

Summary

Most scientists surveyed do not support self-governance for human gene editing research, citing concerns like conflicts of interest and the need for broader input. They advocate for interdisciplinary and public involvement in developing ethical guidelines for this rapidly advancing field.

Keywords:

gene editing governance oversight survey

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Area of Science:

Biotechnology
Bioethics
Genetics

Background:

Human gene editing research is rapidly advancing.
International organizations are actively discussing governance frameworks for this research.
The role of scientists in shaping these governance structures is a key consideration.

Purpose of the Study:

To survey U.S.-based scientists on their views regarding the governance of human gene editing research.
To understand scientists' opinions on their own role in developing research governance.
To identify scientists' preferred models for governing human gene editing.

Main Methods:

Survey of 212 U.S.-based scientists involved in genome editing.
Analysis of quantitative responses regarding self-governance.
Qualitative analysis of open-ended responses detailing reasons and preferred governance models.

Main Results:

A majority of surveyed scientists do not believe scientists should self-govern human gene editing research.
Key reasons cited include conflicts of interest, potential "bad apples," historical precedents, and limited scientific expertise for governance.
Scientists favor governance models that incorporate interdisciplinary professional and public input.

Conclusions:

The study reveals a significant shift away from traditional scientific professional autonomy in the context of human gene editing.
Scientists express a desire for broader, inclusive governance structures involving diverse stakeholders.
These findings can inform the development of effective and ethically sound governance approaches for human gene editing research.