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Related Experiment Videos

Raynaud's phenomenon: a review.

L T Cotton, O Khan

    International Angiology : a Journal of the International Union of Angiology
    |October 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Raynaud's phenomenon often stems from autoimmune issues causing failed vasodilation, not just sympathetic overactivity. Factors like heredity, sex hormones, and blood changes contribute, with treatments like sympathectomy frequently failing.

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    Area of Science:

    • Vascular biology
    • Autoimmune diseases
    • Endocrinology

    Background:

    • Raynaud's phenomenon is typically secondary to other conditions, often involving autoimmune processes.
    • The underlying cause is more frequently a failure of vasodilation rather than sympathetic nervous system overactivity.
    • Vascular dysfunction occurs at the arteriolar and capillary levels in most cases, not just digital arteries.

    Purpose of the Study:

    • To explore the multifactorial etiology of Raynaud's phenomenon.
    • To investigate the role of various physiological and genetic factors in vascular control.
    • To clarify the mechanisms underlying vasodilation failure in Raynaud's phenomenon.

    Main Methods:

    • Analysis of existing literature on Raynaud's phenomenon etiology.

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  • Review of studies on vascular control mechanisms, including thermal entrainment.
  • Examination of factors such as genetics, hormones, blood viscosity, and platelet activity.

    • Main Results:

    • Raynaud's phenomenon is linked to autoimmune disorders, with vasodilation failure being a key issue.
    • Heredity and sex hormones (particularly around ovulation) influence vascular control.
    • Elevated blood viscosity, increased red blood cell rigidity, and hyperactive platelets are observed.
    • Myxedema is a common comorbidity (16%), and prostaglandin metabolism's role remains unclear.
    • Surgical sympathectomy demonstrates a high failure rate (81%).

    Conclusions:

    • Raynaud's phenomenon is a complex condition with diverse underlying causes, often autoimmune.
    • Vascular control is influenced by systemic factors including hormones and blood composition.
    • Current understanding suggests a multifactorial etiology, necessitating further research into specific mechanisms.