Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

567
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
567
Somatosensory, Motor, and Association Cortex01:24

Somatosensory, Motor, and Association Cortex

891
The somatosensory cortex in the parietal lobes is crucial for interpreting sensory data such as touch, temperature, and proprioception. The somatosensory cortex, situated in the parietal lobes, plays a vital role in interpreting sensory information like touch, temperature, and proprioception—awareness of body position. This specialized brain region features an organized structure wherein neurons at the top primarily process sensations originating from the lower body. In contrast, those at...
891
Motor and Sensory Areas of the Cortex01:14

Motor and Sensory Areas of the Cortex

4.5K
The cerebral cortex, the brain's outermost layer, is pivotal in processing complex cognitive tasks, emotions, and various sensory inputs and executing voluntary motor activities. This intricate structure is divided into three primary functional areas: the motor areas, sensory areas, and association areas.
Motor Areas
The motor areas located in the frontal lobe are central to controlling voluntary movements. This region is further subdivided into the primary motor cortex and the premotor cortex....
4.5K
Higher Mental Functions of Brain: Learning and Memory01:26

Higher Mental Functions of Brain: Learning and Memory

956
Memory is one of the most vital higher mental functions of the brain. Memory is closely related to learning because it enables us to retain information and experiences from our past to use them in our present life. It also helps us to remember facts, events, and skills, such as riding a bike or swimming. There are two types of memory — declarative memory, which involves memorizing facts or events, and procedural memory, which enables us to remember how to do something like writing or...
956
Association Areas of the Cortex01:21

Association Areas of the Cortex

6.1K
Association areas are regions of the cerebral cortex that do not have a specific sensory or motor function. Instead, they integrate and interpret information from various sources to enable higher cognitive processes such as memory, learning, and decision-making. Some key association areas include the following:
Prefrontal Association Area: This area is located in the frontal lobe and is involved in planning, decision-making, and moderating social behavior. It connects with primary motor areas,...
6.1K
Role of Hippocampus in Memory01:19

Role of Hippocampus in Memory

504
The hippocampus, a critical brain structure, plays an essential role in memory processing, particularly in the formation and retrieval of memory. This small, seahorse-shaped region is located within the medial temporal lobe, with one hippocampus in each brain hemisphere. Experimental studies involving lesions in the hippocampi of rats have demonstrated significant impairments in tasks such as object recognition and maze navigation, indicating the hippocampus involvement in both recognition and...
504

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Integrating community Live Reviews into academic publishing: an exploratory study.

Research integrity and peer review·2026
Same author

Openness about animal research increases public support.

Nature neuroscience·2022
Same author

Mediodorsal Thalamus Is Critical for Updating during Extradimensional Shifts But Not Reversals in the Attentional Set-Shifting Task.

eNeuro·2022
Same author

Corticocortical and Thalamocortical Changes in Functional Connectivity and White Matter Structural Integrity after Reward-Guided Learning of Visuospatial Discriminations in Rhesus Monkeys.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2020
Same author

Preserved extrastriate visual network in a monkey with substantial, naturally occurring damage to primary visual cortex.

eLife·2019
Same author

Retrosplenial cortex and its role in spatial cognition.

Brain and neuroscience advances·2018
Same journal

Diving exposure and pulmonary stress.

The Journal of physiology·2026
Same journal

Systems modelling of mitochondrial dynamics in different exercise regimes.

The Journal of physiology·2026
Same journal

Central leptin resistance precedes obesity and drives early endocrine dysfunction.

The Journal of physiology·2026
Same journal

Decoding the molecular memory of obesity using machine learning and microRNA dynamics.

The Journal of physiology·2026
Same journal

Kinematic-calcium loops unravel impaired excitation-contraction coupling in MELAS-affected cardioids.

The Journal of physiology·2026
Same journal

hERG1 channels and potential therapeutics for long QT syndrome.

The Journal of physiology·2026
See all related articles

Related Experiment Video

Updated: Sep 4, 2025

Multi-layer Cortical Ca2+ Imaging in Freely Moving Mice with Prism Probes and Miniaturized Fluorescence Microscopy
10:35

Multi-layer Cortical Ca2+ Imaging in Freely Moving Mice with Prism Probes and Miniaturized Fluorescence Microscopy

Published on: June 13, 2017

31.3K

Cortico-thalamocortical interactions for learning, memory and decision-making.

Brook A L Perry1, Juan Carlos Mendez1,2, Anna S Mitchell1

  • 1Department of Experimental Psychology, University of Oxford, Oxford, UK.

The Journal of Physiology
|July 19, 2022
PubMed
Summary
This summary is machine-generated.

Investigating cortico-thalamocortical networks, this study examines how communication between the mediodorsal thalamus (MD) and prefrontal cortex supports learning and decision-making in macaques.

Keywords:
anterior thalamusbehaviourdecision makingmediodorsal thalamusneuroimagingneurophysiologyprefrontal cortexpulvinar

More Related Videos

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex
09:00

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex

Published on: April 15, 2015

12.4K
Combined Shuttle-Box Training with Electrophysiological Cortex Recording and Stimulation as a Tool to Study Perception and Learning
08:43

Combined Shuttle-Box Training with Electrophysiological Cortex Recording and Stimulation as a Tool to Study Perception and Learning

Published on: October 22, 2015

10.4K

Related Experiment Videos

Last Updated: Sep 4, 2025

Multi-layer Cortical Ca2+ Imaging in Freely Moving Mice with Prism Probes and Miniaturized Fluorescence Microscopy
10:35

Multi-layer Cortical Ca2+ Imaging in Freely Moving Mice with Prism Probes and Miniaturized Fluorescence Microscopy

Published on: June 13, 2017

31.3K
Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex
09:00

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex

Published on: April 15, 2015

12.4K
Combined Shuttle-Box Training with Electrophysiological Cortex Recording and Stimulation as a Tool to Study Perception and Learning
08:43

Combined Shuttle-Box Training with Electrophysiological Cortex Recording and Stimulation as a Tool to Study Perception and Learning

Published on: October 22, 2015

10.4K

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Systems Neuroscience

Background:

  • The thalamus and cortex exhibit functional and anatomical interconnectivity, sharing developmental pathways.
  • Mediodorsal thalamus (MD) and prefrontal cortex interactions are critical for learning and adaptive decision-making.
  • Cortico-thalamocortical networks, including anterior thalamus and pulvinar, modulate cognitive functions.

Purpose of the Study:

  • To investigate the timing and importance of cortico-MD thalamocortical network communication during a rapid learning and memory discrimination task.
  • To gather evidence of MD-prefrontal cortex neural network communication in awake, behaving non-human primates.
  • To elucidate the mechanisms underlying thalamic nucleus interactions in cognitive processes.

Main Methods:

  • Electrophysiological recordings and behavioral analysis in awake, behaving male rhesus macaques.
  • Focus on cortico-mediodorsal thalamus neural network communication.
  • Utilizing a rapid learning and memory discrimination task.

Main Results:

  • Evidence is being collected on MD-prefrontal cortex neural network communication.
  • The study aims to establish the critical periods for cortico-MD thalamocortical communication.
  • Current findings suggest MD and anterior thalamus are key for frontotemporal communication, while pulvinar is crucial for frontoparietal communication.

Conclusions:

  • Further research is needed to identify mechanisms governing thalamic nucleus interactions in learning, memory, and decision-making.
  • Understanding these cortico-thalamocortical interactions is vital for advancing knowledge of human brain function.
  • This research may inform strategies for treating cognitive deficits in neurological disorders and neurodegeneration.