Engineering a Nano/Biointerface for Cell and Organ-Selective Drug Delivery

Area of Science:

• Nanomedicine and drug delivery
• Biomaterials science
• Surface chemistry

Background:

• Nanomedicine offers promising therapeutic potential, but clinical applications are limited.
• Targeting specific tissues beyond the liver remains a significant hurdle for nanomedicine.
• Protein corona formation on nanoparticles hinders targeted drug delivery by masking ligands.

Purpose of the Study:

• To explore the influence of nanoparticle surface properties on protein corona formation.
• To review advancements in engineering the nano/bio interface for targeted delivery.
• To discuss strategies for overcoming protein corona challenges in nanomedicine.

Main Methods:

• Analysis of surface properties influencing protein corona composition.
• Review of engineering strategies for nano/bio interface modification.
• Discussion of protein-corona-mediated targeting mechanisms.

Main Results:

• Surface properties critically dictate protein corona characteristics.
• Engineered nano/bio interfaces show potential for improved targeting.
• Protein corona plays a dual role in modulating nanoparticle biodistribution.

Conclusions:

• Understanding and engineering the protein corona is essential for effective nanomedicine.
• Future strategies should focus on rational design informed by nano/bio interface science.
• Overcoming protein corona limitations will unlock broader clinical applications for nanomedicine.