Related Experiment Video
Updated: Sep 4, 2025
05:07
Author Spotlight: Development and Characterization of a Mouse Model for Abdominal Aortic Aneurysm
Published on: August 2, 2024
1.0K
Antithrombotic Therapy for Aortic Aneurysms: A Systematic Review and Meta-Analysis
Kitty H F Wong1, Petar Zlatanovic2, David C Bosanquet3
1Bristol Centre for Surgical Research, Bristol Medical School, University of Bristol, Bristol, UK; North Bristol NHS Trust, Bristol, UK.
Summary
Antithrombotic therapy for aortic aneurysms shows mixed results. Antiplatelet agents may reduce mortality after intervention, but anticoagulants increase risks. High-quality trials are needed for definitive answers on antithrombotic use.
Area of Science:
- Vascular Surgery
- Pharmacology
- Clinical Outcomes Research
Background:
- The role of antithrombotic therapy in managing aortic and peripheral aneurysms remains uncertain.
- Existing evidence is fragmented, necessitating a comprehensive review of its impact on patient outcomes.
Conclusions:
- Current data quality on antithrombotic therapy for aneurysms is low.
- Antiplatelet therapy appears beneficial post-intervention for AAA, while anticoagulants pose increased risks.
- Further large-scale, well-designed trials are essential to clarify the therapeutic role of antithrombotics in aneurysm management.
Related Concept Videos
01:26Aneurysm III: Interprofessional Care
22
Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...
22
01:21Aneurysm II: Clinical Manifestations and Diagnostic Studies
21
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
21
01:25Aortic Regurgitation III: Medical Management
38
Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
38
01:22Aneurysm IV: Nursing Management
18
Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...
18
01:26Atherosclerosis III: Management
31
Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
31
01:30Aneurysm I: Introduction
25
An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
25