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Related Concept Videos

Development of the Heart01:27

Development of the Heart

1.2K
The development of the human heart, a crucial organ, commences from the mesoderm on the 18th or 19th day after fertilization. This process initiates in the cardiogenic area, a group of mesodermal cells at the embryo's head end, which evolves into elongated strands known as cardiogenic cords. These cords undergo a transformation to form hollow-centered endocardial tubes.
As the embryo undergoes lateral folding, these paired tubes approach each other, merging into a single primitive heart...
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Layers of the Heart Wall01:15

Layers of the Heart Wall

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The heart wall comprises three distinct layers: the epicardium, myocardium, and endocardium. The outermost layer, the epicardium, is the visceral layer of the serous pericardium, featuring a thin, transparent mesothelial surface and an inner layer of areolar connective tissue with fat deposits that increase with age.
The myocardium, the thickest layer, consists of cardiac muscle cells interconnected by intercalated discs and crisscrossing connective tissue fibers. These muscle fibers contract...
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Chambers of the Heart01:16

Chambers of the Heart

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The human heart is a complex organ made up of four chambers: the right and left atria and the right and left ventricles. These internal chambers are separated by partitions known as the interatrial and interventricular septa. The exterior of the heart features a groove known as the coronary sulcus that demarcates the atria from the ventricles, while the anterior and posterior interventricular sulci distinguish between the two ventricles.
Deoxygenated blood from the body is received in the right...
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Heart Valves01:16

Heart Valves

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The human heart is a complex organ with an intricate system of valves that regulate blood flow. There are two main types of valves: atrioventricular (AV) valves and semilunar valves.
The AV valves prevent the backflow of blood from the ventricles to the atria during ventricular contraction. These valves function with the assistance of the chordae tendineae and papillary muscles. When the ventricles are relaxed, the chordae tendineae are slack, allowing blood to flow from the atria into the...
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Anatomy of the Heart01:27

Anatomy of the Heart

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The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
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Overview of the Heart01:07

Overview of the Heart

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The heart, a muscular organ located in the chest, functions as the body's pump, circulating blood through the vascular system. It has four chambers: two atria on top and two ventricles below. The right atrium receives deoxygenated blood from the body and passes it to the right ventricle, which pumps it to the lungs for oxygenation. The left atrium receives oxygenated blood from the lungs and transfers it to the left ventricle, which pumps it to the rest of the body.
The heart's structure...
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Related Experiment Video

Updated: Sep 4, 2025

Semi-automated Optical Heartbeat Analysis of Small Hearts
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Semi-automated Optical Heartbeat Analysis of Small Hearts

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Hearts by design.

Michael V Sefton1, Craig A Simmons2

  • 1Medicine by Design, Institute of Biomedical Engineering, University of Toronto, Toronto, ON, Canada.

Science (New York, N.Y.)
|July 20, 2022
PubMed
Summary
This summary is machine-generated.

Researchers biofabricated scalable helical heart tissue patterns, significantly improving the organ

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Cardiovascular Science

Background:

  • Heart disease remains a leading cause of mortality worldwide.
  • Current treatments for heart failure have limitations.
  • Biofabrication offers a promising avenue for cardiac tissue engineering.

Purpose of the Study:

  • To develop a scalable method for biofabricating heart tissue with a helical pattern.
  • To investigate if this helical structure enhances cardiac pumping function.

Main Methods:

  • Utilized advanced biofabrication techniques to create aligned cardiac tissue constructs.
  • Engineered a specific helical pattern within the tissue architecture.
  • Assessed the contractile and pumping capabilities of the biofabricated tissues.

Main Results:

  • Successfully achieved scalable production of heart tissue with a defined helical pattern.
  • Demonstrated significantly augmented pumping efficiency in the helical tissue constructs compared to non-helical controls.
  • Tissue exhibited organized cellular alignment and synchronous contraction.

Conclusions:

  • Scalable biofabrication of helical cardiac tissue is feasible.
  • The helical pattern is crucial for enhancing cardiac pumping function.
  • This approach holds potential for developing improved cardiac therapies.