Related Experiment Video
Updated: Sep 4, 2025

Preparation, Procedures and Evaluation of Platelet-Rich Plasma Injection in the Treatment of Knee Osteoarthritis
Published on: January 4, 2019
SELF-MANAGEMENT PROGRAM (PARQVE) IMPROVES QUALITY OF LIFE IN SEVERE KNEE OSTEOARTHRITIS
Raphael Carvalho Biscaro1, Pablo Gabriel Garcia Ochoa1, Guilherme Pereira Ocampos1
1Universidade de São Paulo, Faculty of Medicine, Hospital das Clínicas, Institute of Orthopedics and Traumatology, HC-FMUSP, São Paulo, SP, Brazil.
Objective:
To evaluate the effects of the self-management program PARQVE in patients with severe knee osteoarthritis (KOA).
Methods:
Prospective randomized controlled clinical trial with 65 grade IV Kelgren & Lawrence (K&L) KOA patients who were allocated into groups: Control (CG) and Intervention (IG). Both groups received usual care. IG also participated in two days of multi-professional interventions about OA (causes and treatment) and received the program's DVD and book. Standing X-rays were obtained at inclusion and Ahlback's classification was registered. Western Ontario and McMaster Universities Index (WOMAC), Numerical Rating Scale (NRS), Lequesne, weight, and body mass index (BMI) were obtained at inclusion, and after 6, 12 and 24 months.
Results:
Groups were similar at baseline, despite higher WOMAC stiffness scores and a greater number of Ahlback's grade 4 and 5 in the IG. Only the IG improved WOMAC and total functions (p<0.001) during the study period above 12%, but did not reach the minimal clinically important difference of 20%. Best results were in one year. Non-significant improvements were observed without changes in body composition (P>0.05).
Conclusions:
Patients with severe KOA have mild to moderate function and quality of life improvement due to self-management program (PARQVE).
Related Concept Videos
Chronic Obstructive Pulmonary Disease-V: Management
Smoking Cessation
Rheumatic Heart Disease III: Medical Management
Peripheral Artery Disease IV: Nursing Management
COPD: Management Using Bronchodilators and Corticosteroids
Atherosclerosis III: Management
Peripheral Artery Disease III: Interprofessional Care

