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Polyether-urethane elastomers for small-diameter arterial prostheses.

D Annis

    Life Support Systems : the Journal of the European Society for Artificial Organs
    |January 1, 1987
    PubMed
    Summary
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    Flexible synthetic arterial prostheses made from polyether-urethane urea offer improved compatibility and durability. These novel vascular grafts demonstrate good two-year patency in canine carotid artery replacements.

    Area of Science:

    • Biomaterials Science
    • Vascular Surgery
    • Polymer Chemistry

    Background:

    • Traditional synthetic arterial prostheses often use rigid polymers, limiting their resemblance to natural arteries.
    • The mechanical properties and structural form of existing prostheses are suboptimal, impacting tissue and blood compatibility.
    • Developing compliant and flexible vascular grafts is crucial for improved performance and integration.

    Purpose of the Study:

    • To develop a compliant and flexible synthetic arterial prosthesis with improved mechanical properties and structural integrity.
    • To enhance tissue and blood compatibility for better long-term durability.
    • To evaluate the performance of a novel microfibrous arterial prosthesis in a preclinical model.

    Main Methods:

    • Fabrication of a small-diameter arterial prosthesis using electrostatically spun microfibers.

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  • Material used: polyether-urethane urea (Biomer).
  • In vivo evaluation in dogs, replacing the common carotid artery.

    • Main Results:

    • The electrostatically spun microfibrous prosthesis demonstrated good flexibility and a delicate structure.
    • The polyether-urethane urea prosthesis exhibited good tissue and blood compatibility.
    • Two-year patency was achieved for the prostheses used in common carotid artery replacement in dogs.

    Conclusions:

    • Compliant and flexible arterial prostheses with delicate structures can be fabricated using advanced materials like polyether-urethane urea.
    • These novel prostheses offer improved compatibility and durability compared to rigid synthetic grafts.
    • The demonstrated two-year patency supports the potential clinical application of these vascular grafts.