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Advancing High-Resolution Imaging of Virus Assemblies in Liquid and Ice
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Liquid-EM goes viral - visualizing structure and dynamics.

Deborah F Kelly1, Liza-Anastasia DiCecco2, G M Jonaid3

  • 1Department of Biomedical Engineering, Pennsylvania State University, University Park, PA 16802, USA; Center for Structural Oncology, Pennsylvania State University, University Park, PA 16802, USA; Materials Research Institute, Pennsylvania State University, University Park, PA 16802, USA.

Current Opinion in Structural Biology
|July 22, 2022
PubMed
Summary
This summary is machine-generated.

Liquid electron microscopy (EM) offers real-time insights into dynamic reactions in solution, complementing cryo-EM. This technique is revolutionizing nanoscale imaging by enabling the study of viral assemblies and host-pathogen interactions.

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Area of Science:

  • Structural Biology
  • Microscopy Techniques
  • Biophysics

Background:

  • Cryo-electron microscopy (cryo-EM) is a powerful tool for structural determination.
  • Observing dynamic biological processes in solution at high resolution remains a challenge.
  • Liquid electron microscopy (liquid-EM) emerges as a complementary technique to cryo-EM.

Purpose of the Study:

  • To explain the growing popularity and applications of liquid-EM.
  • To review key experiments and workflows in liquid-EM for viral studies.
  • To highlight the potential of liquid-electron tomography in biomedical research.

Main Methods:

  • Development of specimen preparation workflows for liquid EM.
  • Establishment of data collection strategies for dynamic reactions in solution.
  • Implementation of computational processes for high-resolution imaging.

Main Results:

  • Achieved first high-resolution virus structures using liquid EM.
  • Demonstrated liquid-EM's capability in studying viral assemblies and host-pathogen interactions.
  • Showcased liquid-electron tomography's potential for real-time monitoring of viral entry.

Conclusions:

  • Liquid-EM provides real-time data of dynamic reactions, complementing cryo-EM.
  • The technique is poised to advance biomedical research, particularly in virology.
  • Liquid-EM heralds a new era of dynamic nanoscale imaging, termed the 'real-time revolution'.