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RETRACTED: Kelly et al. Delineating Conformational Variability in Small Protein Structures Using Combinatorial

Deborah F Kelly^1,2, G M Jonaid^1,2,3, Liam Kaylor^1,2,4

¹Department of Biomedical Engineering, Pennsylvania State University, University Park, PA 16802, USA.

|November 27, 2025

Summary

This article retraction addresses concerns regarding the methodology and findings of a study on protein structure analysis. The original research on conformational variability in small proteins has been withdrawn due to significant issues.

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Area of Science:

Structural biology
Biophysics
Computational biology

Background:

Understanding protein conformational variability is crucial for biological function.
Previous studies have explored methods for analyzing protein structures.
The article "Delineating Conformational Variability in Small Protein Structures Using Combinatorial Refinement Strategies" presented novel approaches.

Purpose of the Study:

To evaluate the methods used in the retracted article.
To address the scientific community's concerns regarding the validity of the findings.
To ensure the integrity of scientific record in structural biology.

Main Methods:

Retraction involves a thorough review of the original study's data and methodology.
Assessment of the combinatorial refinement strategies employed.
Evaluation of the statistical significance and reproducibility of the results.

Main Results:

The review identified significant flaws in the methodology.
Concerns were raised about the interpretation of conformational variability data.
The findings presented in the original article were deemed unreliable.

Conclusions:

The article "Delineating Conformational Variability in Small Protein Structures Using Combinatorial Refinement Strategies" is retracted.
The retraction is based on identified methodological and data interpretation issues.
This action upholds scientific rigor and transparency in structural biology research.