Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

116
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
116
Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

202
Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
202
Positive Symptoms of Schizophrenia: Hallucinations and Delusions01:30

Positive Symptoms of Schizophrenia: Hallucinations and Delusions

214
Schizophrenia is a complex mental health disorder that can manifest with various positive symptoms, including thought, movement, and behavior disorders. These symptoms significantly disrupt cognitive and motor functions, leading to profound effects on an individual's ability to engage with the world.
Thought Disorders
Disorganized and unusual thought processes mark thought disorders in schizophrenia. One key feature is disorganized speech, where an individual's conversation includes...
214
Schizophrenia01:17

Schizophrenia

205
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
205
Personality Disorders: Paranoid and Schizoid01:22

Personality Disorders: Paranoid and Schizoid

155
Personality disorders represent enduring cognition, affect, and behavior patterns that significantly deviate from societal norms. These maladaptive traits often lead to difficulties in various domains, including interpersonal relationships, occupational settings, and overall psychological well-being. Paranoid personality disorder and schizoid personality disorder are two distinct conditions marked by odd or eccentric behavior.
Paranoid Personality Disorder
Paranoid personality disorder is...
155
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

916
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
916

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Altered functional hierarchical and sequential organization in individuals with schizophrenia during auditory processing.

NeuroImage·2026
Same author

Two decades of progress in schizophrenia: Evolution, current insights, and future directions.

Spanish journal of psychiatry and mental health·2026
Same author

Decomposing neuroanatomical heterogeneity in depression: insights from an ENIGMA major depressive disorder working group study in 5146 individuals.

Translational psychiatry·2026
Same author

Mapping behavioural mechanisms linking childhood maltreatment, cognition, impulsivity, and suicidality in bipolar disorder: A network approach.

Translational psychiatry·2026
Same author

Visual versus automated collateral scoring on CT angiography for predicting outcome after endovascular therapy for large-vessel occlusion stroke: a prospective multicentre study.

Neuroradiology·2026
Same author

Specialized, integrative treatment for long-standing eating disorders: early insights and implications.

Journal of eating disorders·2026
Same journal

Within-subject alterations in CSF and blood flow dynamics following rhythm-control intervention in atrial fibrillation: An exploratory multimodal MRI study.

NeuroImage. Clinical·2026
Same journal

Diffusion MRI of white matter alterations in chronic traumatic brain injury: a systematic review and meta-analysis.

NeuroImage. Clinical·2026
Same journal

Decoding functional changes in the brain following ischemic stroke: a multimodal feature approach integrating fNIRS with machine learning and deep learning.

NeuroImage. Clinical·2026
Same journal

Structural brain alterations in chronic primary pain: a multimodal MRI study.

NeuroImage. Clinical·2026
Same journal

Using functional MRI neurofeedback to modulate self-blame in major depressive disorder: A pilot study.

NeuroImage. Clinical·2026
Same journal

Language network reorganization in temporal lobe epilepsy: insights from task-based functional MRI.

NeuroImage. Clinical·2026
See all related articles

Related Experiment Video

Updated: Sep 3, 2025

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
09:29

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Published on: January 9, 2015

15.5K

Negative schizophrenic symptoms as prefrontal cortex dysfunction: Examination using a task measuring goal neglect.

Paola Fuentes-Claramonte1, Núria Ramiro2, Llanos Torres3

  • 1FIDMAG Germanes Hospitalàries Research Foundation, Barcelona, Spain; CIBERSAM (Centro de Investigación Biomédica en Red de Salud Mental), Barcelona, Spain.

Neuroimage. Clinical
|July 23, 2022
PubMed
Summary
This summary is machine-generated.

Schizophrenia patients with high negative symptoms show reduced prefrontal cortex activation, particularly in the left anterior frontal cortex. This brain dysfunction is linked to negative symptoms like lack of volition.

Keywords:
Executive functionFrontal lobesNegative symptomsSchizophreniafMRI

More Related Videos

The Attentional Set Shifting Task: A Measure of Cognitive Flexibility in Mice
09:15

The Attentional Set Shifting Task: A Measure of Cognitive Flexibility in Mice

Published on: February 4, 2015

27.6K
Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

335

Related Experiment Videos

Last Updated: Sep 3, 2025

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder
09:29

Signal Attenuation as a Rat Model of Obsessive Compulsive Disorder

Published on: January 9, 2015

15.5K
The Attentional Set Shifting Task: A Measure of Cognitive Flexibility in Mice
09:15

The Attentional Set Shifting Task: A Measure of Cognitive Flexibility in Mice

Published on: February 4, 2015

27.6K
Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
09:14

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging

Published on: March 14, 2025

335

Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Science

Background:

  • Negative symptoms in schizophrenia are hypothesized to stem from prefrontal cortex dysfunction.
  • Previous functional imaging studies have yielded inconsistent results, possibly due to task selection not fully capturing negative symptom aspects like volition.

Purpose of the Study:

  • To investigate the neural correlates of negative symptoms in schizophrenia using functional magnetic resonance imaging (fMRI).
  • To examine brain activation patterns during a task designed to assess goal-directed behavior organization.

Main Methods:

  • fMRI scans were conducted on 24 schizophrenia patients with high negative symptoms (HNS), 25 with absent negative symptoms (ANS), and 30 healthy controls.
  • Participants performed the Computerized Multiple Elements Test (CMET) to evaluate goal neglect.
  • Negative symptoms were assessed using the PANSS and CAINS.

Main Results:

  • HNS patients exhibited hypoactivation in the left anterior frontal cortex, right dorsolateral prefrontal cortex (DLPFC), bilateral anterior insula, and bilateral inferior parietal cortex compared to controls.
  • HNS patients showed reduced activation in the left anterior frontal cortex, left DLPFC, and left inferior parietal cortex compared to ANS patients.
  • Reduced activation in the left anterior frontal cortex and bilateral inferior parietal cortex persisted after controlling for disorganization scores.

Conclusions:

  • Reduced prefrontal cortex activation, especially in the left anterior frontal cortex, is a functional correlate of negative symptoms in schizophrenia.
  • Unexpectedly, reduced inferior parietal cortex activation was also observed, potentially indicating its role in cognitive control and regulation.