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Published on: June 15, 2018
miRNA expression in COVID-19
Kiarash Roustai Geraylow1, Romina Hemmati1, Sepideh Kadkhoda2
1Student Research Committee, Semnan University of Medical Sciences, Semnan, Iran.
Abstract:
Coronavirus disease 2019 (COVID-19) is regarded as a challenge in health system. Several studies have assessed the immune-related aspect of this disorder to identify the host-related factors that affect the course of COVID-19. microRNAs (miRNAs) as potent regulators of immune responses have gained much attention in this regard. Recent studies have shown aberrant expression of miRNAs in COVID-19 in association with disease course. Differentially expressed miRNAs have been enriched in pathways related with inflammation and antiviral immune response. miRNAs have also been regarded as potential therapeutic targets in COVID-19, particularly for management of pathological consequences of COVID-19. In the current review, we summarize the data about dysregulation of miRNAs in COVID-19.
Insights
microRNAs (miRNAs) are key regulators of immune responses and show altered expression in COVID-19. Dysregulated miRNAs are linked to inflammation and antiviral pathways, offering potential therapeutic targets for managing COVID-19.
Area of Science:
- Immunology
- Molecular Biology
- Virology
Background:
- Coronavirus disease 2019 (COVID-19) presents significant health system challenges.
- Host-related factors influencing COVID-19 progression are under investigation.
- MicroRNAs (miRNAs) are crucial regulators of immune responses.
Purpose of the Study:
- To review and summarize the current understanding of microRNA (miRNA) dysregulation in COVID-19.
- To highlight the role of miRNAs in immune responses related to COVID-19.
- To explore the potential of miRNAs as therapeutic targets for COVID-19.
Main Methods:
- Literature review of studies investigating microRNAs in COVID-19.
- Analysis of data on aberrant miRNA expression in COVID-19 patients.
- Examination of pathways enriched by differentially expressed miRNAs.
Main Results:
- MicroRNA (miRNA) expression is significantly altered in individuals with COVID-19.
- Differentially expressed miRNAs are associated with inflammatory and antiviral immune pathways.
- These findings suggest miRNAs play a critical role in COVID-19 pathogenesis.
Conclusions:
- MicroRNA (miRNA) dysregulation is a notable feature of COVID-19.
- miRNAs are implicated in the immune and inflammatory responses to SARS-CoV-2 infection.
- Targeting miRNAs may offer a novel therapeutic strategy for COVID-19 management.
