Related Experiment Video
Updated: Sep 3, 2025
07:23
Dual CRISPR-Interference Strategy for Targeting Synthetic Lethal Interactions Between Non-Coding RNAs in Cancer Cells
Published on: May 30, 2025
607
Emerging Roles and Potential Applications of Non-Coding RNAs in Cervical Cancer
Deepak Parashar1, Anupam Singh2, Saurabh Gupta2
1Department of Obstetrics and Gynecology, Medical College of Wisconsin, Milwaukee, MI 53226, USA.
Genes
|July 27, 2022
Summary
Non-coding RNAs (ncRNAs) are key regulators in cervical cancer (CC) progression and metastasis. Understanding their roles offers new therapeutic targets for this prevalent women's cancer.
Area of Science:
- Oncology
- Molecular Biology
- Genomics
Background:
- Cervical cancer (CC) remains a leading global cancer in women, with limited options for advanced stages.
- Metastasis mechanisms and novel therapeutic targets are critical for improving CC patient outcomes.
- Non-coding RNAs (ncRNAs) are increasingly recognized as crucial regulators in various biological processes, including cancer.
Purpose of the Study:
- To review the multifaceted roles of ncRNAs in cervical cancer.
- To explore ncRNA involvement in CC progression, metastasis, and therapeutic resistance.
- To discuss ncRNA-targeting strategies and emerging technologies for CC management.
Main Methods:
- Comprehensive literature review of ncRNA functions in cervical cancer.
- Analysis of ncRNA involvement in tumor microenvironment and immunology.
- Examination of advanced technologies for ncRNA-based CC therapies.
Main Results:
- ncRNAs significantly influence CC progression, metastasis, and chemo-resistance.
- ncRNAs play roles in human papillomavirus (HPV) regulation and metabolic reprogramming in CC.
- ncRNAs are implicated in CC diagnosis, prognosis, and the tumor microenvironment.
Conclusions:
- ncRNAs represent promising biomarkers and therapeutic targets for cervical cancer.
- Targeting ncRNAs, utilizing technologies like CRISPR-Cas9 and exosomes, holds potential for CC treatment.
- Further research into ncRNA functions will enhance understanding and management of cervical cancer.
More Related Videos
12:13Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
Published on: November 19, 2019
6.9K
10:27In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions
Published on: October 21, 2022
1.6K
Related Concept Videos
02:39lncRNA - Long Non-coding RNAs
8.8K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
8.8K
01:20Types of RNA
6.1K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
RNA Performs Diverse...
6.1K
01:22MicroRNAs
3.1K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.1K
02:30siRNA - Small Interfering RNAs
17.0K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
17.0K
02:15Experimental RNAi
6.2K
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
6.2K
01:23RNA Interference
26.4K
RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
26.4K