An Insight into Preparatory Methods and Characterization of Orodispersible Film-A Review.
1Department of Pharmaceutics, College of Pharmacy, Jazan University, Jazan 45142, Saudi Arabia.
Pharmaceuticals (Basel, Switzerland)
|July 27, 2022
Summary
Novel orodispersible films (ODFs) offer a promising drug delivery system for improved patient compliance and efficacy. These water-free, fast-dissolving films benefit pediatric, geriatric, and bedridden patients, enhancing drug absorption and patient outcomes.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
- Materials Science
Background:
- Traditional drug delivery faces challenges in cost, complexity, and patient adherence.
- Novel drug delivery systems aim to improve safety, efficacy, and patient acceptability.
- Orodispersible films (ODFs) represent an innovative approach to oral drug administration.
Purpose of the Study:
- To review the preparation, characterization, and evaluation of ODFs.
- To identify factors influencing ODF formulation.
- To explore potential drug candidates and polymers for ODF applications.
Main Methods:
- Literature review focusing on ODF preparation and characterization techniques.
- Analysis of solvent casting as a primary ODF manufacturing method.
- Evaluation of film-forming polymers for ODF development.
Main Results:
- ODFs offer advantages over fast-disintegrating tablets, including rapid disintegration and improved bioavailability.
- The solvent casting method is widely used for ODF preparation.
- Film-forming polymers are crucial for achieving fast disintegration, enhanced dissolution, and uniform drug content.
Conclusions:
- ODFs provide an effective, safe, and patient-friendly drug delivery alternative.
- This technology is particularly beneficial for specific patient populations and emergency situations.
- Further research into drug candidates and polymers can optimize ODF performance.
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