Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dysrhythmias I: Introduction01:15

Dysrhythmias I: Introduction

160
Dysrhythmias refers to abnormalities in the heart's rhythm. They result from disruptions in the heart's electrical conduction system, which includes the sinoatrial(SA)node, atrioventricular(AV) node, the bundle of His, bundle branches, and Purkinje fibers.Definition and PathophysiologyDysrhythmias result from disorders of impulse formation, impulse conduction, or both. The heart contains specialized cells in the sinoatrial node, atrioventricular node, and the bundle of His and Purkinje fibers...
160
Dysrhythmias VI: Management of Dysrhythmias01:25

Dysrhythmias VI: Management of Dysrhythmias

104
Dysrhythmia management involves a multifaceted approach, incorporating pharmacological treatments, medical procedures, surgical interventions, lifestyle modifications, and patient education.Pharmacological ManagementAntiarrhythmic Drugs:Class I (Sodium Channel Blockers): This class includes quinidine and procainamide, which reduce the speed of impulse conduction in the heart, stabilize the cardiac membrane, and control arrhythmias. Quinidine and procainamide are Class IA agents that prolong the...
104
Dysrhythmias II: Classification of Tachyarrhythmias01:28

Dysrhythmias II: Classification of Tachyarrhythmias

133
Tachyarrhythmias are a type of dysrhythmia where the heart rate exceeds 100 beats per minute. Here are some common types of tachyarrhythmias:Sinus TachycardiaSinus tachycardia originates from increased impulses from the sinus node, leading to an elevated heart rate. It is often triggered by stress, fever, or exercise.Patients may experience palpitations, a sensation of a racing heart, dizziness, and chest discomfort.Causes and Risk Factors: Common causes include physical exertion, emotional...
133
Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

18
Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
18
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

30
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
30

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single Ventricle Fontan: The Basics for General Cardiologists.

Methodist DeBakey cardiovascular journal·2026
Same author

Hepatic Alpha-1 Antitrypsin Globules in Compound Heterozygous SERPINA1 Variants Previously Considered Non-Polymerizing: A Case Report.

International journal of molecular sciences·2026
Same author

Intermittent Levosimendan Administration for Advanced Heart Failure Treatment in Adults with Congenital Heart Disease (Levo-ACHD Study).

Medicina (Kaunas, Lithuania)·2026
Same author

Precision electrophysiology meets surgery: a new paradigm in repaired tetralogy of Fallot?

European heart journal·2026
Same author

Artificial Intelligence-Enhanced Implantable Loop Recorders in Pediatric Patients: Effects on Device Performance and Clinical Workflow in a Single-Center Experience.

Journal of cardiovascular electrophysiology·2026
Same author

Wearable Cardioverter-Defibrillator in Adult Congenital Heart Disease: A Bridge to Decision, Recovery, and Advanced Therapies.

Heart failure reviews·2026

Related Experiment Video

Updated: Sep 3, 2025

Translational Rabbit Model of Chronic Cardiac Pacing
06:14

Translational Rabbit Model of Chronic Cardiac Pacing

Published on: January 6, 2023

2.7K

Leadless pacemaker in Twiddler's syndrome: A case report.

Valentino Ducceschi1, Marcello De Divitiis1, Giovanni Domenico Ciriello1

  • 1Electrophysiology and Cardiac Pacing Unit, Pellegrini Hospital, Naples, Italy.

Pacing and Clinical Electrophysiology : PACE
|July 30, 2022
PubMed
Summary

Twiddler syndrome, a rare cause of pacemaker lead dislodgement, affected a patient with Down syndrome. A leadless pacing system was implanted after device removal.

Keywords:
MicraTwiddler Syndromeleadless pacemaker

More Related Videos

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.6K
Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine
10:08

Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine

Published on: February 17, 2018

13.6K

Related Experiment Videos

Last Updated: Sep 3, 2025

Translational Rabbit Model of Chronic Cardiac Pacing
06:14

Translational Rabbit Model of Chronic Cardiac Pacing

Published on: January 6, 2023

2.7K
Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

10.6K
Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine
10:08

Tachycardia-Induced Cardiomyopathy As a Chronic Heart Failure Model in Swine

Published on: February 17, 2018

13.6K

Area of Science:

  • Cardiology
  • Medical Devices
  • Genetics

Background:

  • Pacemaker implantation is a common procedure for managing cardiac arrhythmias.
  • Lead dislodgement can compromise pacemaker function, necessitating intervention.
  • Twiddler syndrome is an uncommon but recognized cause of lead displacement.

Observation:

  • A 49-year-old male with Down syndrome experienced pacemaker malfunction 3 months post-implantation.
  • The patient presented with high ventricular impedance, loss of sensing, and complete loss of capture.
  • Lead dislodgement due to Twiddler syndrome was identified as the cause.

Findings:

  • Twiddler syndrome led to dual-chamber pacemaker lead dislodgement in this patient.
  • The malfunction resulted in complete loss of pacing capture and sensing.
  • Surgical removal of the dislodged device was performed.

Implications:

  • This case highlights Twiddler syndrome as a critical differential diagnosis for pacemaker failure.
  • It underscores the importance of considering patient behavior and device manipulation.
  • Successful implantation of a leadless pacing system offers an alternative in complex cases.