PREDICTION OF ASTHMA CONTROL STATUS IN SCHOOL-AGE CHILDREN SENSITIZED TO CAT ALLERGENS

The aim: To develop a model for predicting asthma control status in school-age children sensitized to cat allergens.

Materials and methods: The study included 302 children aged 6-17 years who were sensitized to cat allergens. The ALEX² test (Macro Array Diagnostics GmbH, Austria) was used to analyze the sensitization profile in these children. After 12 months of treatment, control of clinical asthma symptoms was achieved in 185 (61.26%) children. Single-factor logistic regression models were constructed to analyze the probability of achieving asthma control in school-age children with sensitization to cat allergens.

Results: It was found that asthma control status depended on the FeNO dynamics after 3 months of treatment, the number of cat allergens to which sensitization was detected, and the duration of exposure to a domestic cat after sensitization tests, which were conducted to verify the allergic capacity to cat allergens. The investigation resulted in the creation of a mathematical model for predicting the probability of asthma control, sensitivity 94.6 (95% CI 90.3 - 97.4) %, specificity - 81.2 (95% CI 72.9 - 87.8) %, PPV = 88.8 (95% CI 84.5 - 92.1) %, NPV = 90.5 (95% CI 83.8 - 94.6) %.

Conclusions: A model for predicting the probability of asthma control was created. The formula is used to calculate the patient's P. P > 0.44 allows predicting the achievement of asthma control after 12 months of treatment.