Soluble lectin-like oxidized low-density Lipoproteinreceptor-1 and recurrent stroke: A nested case-control study

Area of Science:

• Cardiovascular Research
• Neurology
• Biomarker Discovery

Background:

• The prognostic value of soluble lectin-like oxidized low-density lipoproteinreceptor-1 (sLOX-1) for stroke recurrence remains unclear.
• Understanding predictors of recurrent stroke is crucial for patient management and secondary prevention strategies.

Purpose of the Study:

• To investigate the association between sLOX-1 levels and the risk of recurrent stroke.
• To evaluate sLOX-1 as a potential biomarker for improving risk stratification in patients with acute ischemic stroke (AIS) or transient ischemic attack (TIA).

Main Methods:

• A case-control study utilizing data from the Third China National Stroke Registry.
• Included 400 patients with recurrent stroke and 800 matched controls within a 1-year follow-up period.
• Conditional logistic regression analysis was employed to assess the association between sLOX-1 and recurrent stroke.

Main Results:

• Elevated sLOX-1 levels were significantly associated with an increased risk of recurrent stroke (OR 2.23, 95% CI 1.61-3.08) after adjusting for confounders.
• sLOX-1 demonstrated incremental predictive value for recurrent stroke when added to conventional risk models (C-statistic 0.76).
• The association was more pronounced in patients with a prior history of stroke.

Conclusions:

• sLOX-1 is positively associated with the risk of recurrent stroke.
• sLOX-1 may serve as a valuable candidate biomarker for enhancing the risk stratification of recurrent stroke.