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A Lung Sound Analysis in Infants with Risk Factors for Asthma During Acute Respiratory Infection
Hiroko Ishizu1, Hiromi Shioya2, Hiromi Tadaki2
1Department of Pediatrics, Saiseikai Yokohamashi Tobu Hospital, Yokohama, Japan.
Pediatric Allergy, Immunology, and Pulmonology
|August 3, 2022
Summary
Analyzing lung sounds in infants with acute respiratory infection (ARI) revealed significant changes, particularly in those with asthma risk factors. These lung sound biomarkers may help assess airway characteristics in infants.
Area of Science:
- Pediatric Pulmonology
- Biomarkers
- Respiratory Medicine
Background:
- Lung sound parameters are potential biomarkers for airway changes.
- Acute Respiratory Infection (ARI) significantly impacts infant respiratory health.
- Assessing airway characteristics in infants requires reliable diagnostic tools.
Purpose of the Study:
- To investigate lung sound characteristics in infants with ARI.
- To identify potential lung sound biomarkers for airway changes in infants.
- To examine the influence of ARI on lung sounds in infants with asthma risk factors.
Main Methods:
- Utilized a commercial lung sound analyzer to evaluate parameters like A3/AT, B4/AT, RPF75, and RPF50.
- Included 110 infants with ARI and 248 healthy infants aged 6-18 months.
- Stratified analysis was performed on two age groups (6-12 and 13-18 months).
- Assessed asthma development risk factors using a Japanese questionnaire.
Main Results:
- Infants with ARI and a history of wheezing, allergy, or atopic dermatitis showed significantly lower RPF50 values compared to controls.
- In the 6-12 month group, atopy-positive infants with ARI had lower RPF50 values (P=0.003).
- ARI had a more pronounced effect on lung sounds in infants with asthma risk factors.
Conclusions:
- Changes in lung sounds induced by ARI may serve as useful indicators of airway characteristics in infants.
- RPF50 values show potential as biomarkers for respiratory changes in infants with ARI and atopy.
- Further analysis of lung sound alterations can aid in evaluating infant airway conditions.
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