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The Link Between Plasma 25-Hydroxyvitamin D and Lung Function in General and Asthmatic Children
Sara Khan1, Xiao-Mei Mai2, Yue Chen1
1Department of Epidemiology and Community Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON, Canada.
Pediatric Allergy, Immunology, and Pulmonology
|August 4, 2022
Summary
Vitamin D deficiency is common in children. While not linked to general lung function, higher vitamin D levels correlate with better respiratory function in boys with asthma.
Area of Science:
- Pediatric Pulmonology
- Nutritional Epidemiology
- Public Health
Background:
- Vitamin D is crucial for adult respiratory health, but its role in children's pulmonary function is understudied.
- Epidemiological data on vitamin D and pediatric lung function is limited.
- Understanding this relationship is vital for child respiratory health management.
Purpose of the Study:
- To investigate the association between plasma 25-hydroxyvitamin D [25(OH)D] levels and pulmonary function in children.
- To analyze this association in the general pediatric population and specifically in children with asthma.
Main Methods:
- Cross-sectional study using data from 1,421 children aged 6-17 years from the Canadian Health Measures Survey (2007-09).
- Multiple linear regression analysis was employed to assess the relationship.
- Pulmonary function was evaluated using standard lung function tests.
Main Results:
- Twenty percent of participating children exhibited vitamin D deficiency (plasma 25(OH)D < 50 nM).
- No significant association was found between plasma 25(OH)D and pulmonary function in the general pediatric population after adjusting for confounders.
- A positive association was observed between plasma 25(OH)D and FEV0.75, FEV1, and FEV1/FVC in boys with asthma.
Conclusions:
- Plasma 25(OH)D levels are not significantly associated with pulmonary function in the general pediatric population.
- In boys with asthma, higher plasma 25(OH)D concentrations are linked to improved respiratory function.
- Further research is warranted to explore the therapeutic potential of vitamin D supplementation in pediatric asthma.
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