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The latest developments in biomarkers predicting response to immunotherapy

Giandomenico Roviello1, Melissa Bersanelli2, Martina Catalano3

  • 1Department of Health Sciences, Section of Clinical Pharmacology & Oncology, University of Florence, Viale Pieraccini, 6, Florence, 50139, Italy.

Immunotherapy
|August 4, 2022
PubMed

Tweetable abstract Biomarkers predicting response to immune checkpoint inhibitors can facilitate the selection of patients who benefit from immunotherapy, avoiding rapid disease progression in nonresponders and needless toxicity.

Keywords:
biomarkersimmune checkpoints inhibitorsimmunotherapypredictive factorssolid tumors

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Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
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