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Association of lipoprotein(a) with aortic dissection
Yiheng Yang1, Yuting Hong2, Weihua Yang3
1Department of Cardiovascular Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Clinical Cardiology
|August 4, 2022
Summary
High levels of Lipoprotein(a) [Lp(a)] strongly correlate with aortic dissection (AD). This association remains significant even when accounting for other cardiovascular risk factors, highlighting Lp(a) as a key indicator for AD risk.
Area of Science:
- Cardiovascular Medicine
- Genetics and Genomics
- Biochemistry
Background:
- Lipoprotein(a) [Lp(a)] is a known risk factor for cardiovascular diseases including coronary atherosclerotic heart disease, aortic stenosis, stroke, and heart failure.
- The specific association between Lp(a) levels and aortic dissection (AD) requires further elucidation.
Purpose of the Study:
- To investigate the relationship between Lipoprotein(a) [Lp(a)] levels and the risk of aortic dissection (AD).
Main Methods:
- A retrospective case-control study involving 200 patients with AD and 200 matched controls.
- Data collected included demographic information, cardiovascular risk factors, and lipid profiles, with a focus on Lp(a) levels.
- Univariate and multivariate logistic regression analyses were employed to assess the association between Lp(a) and AD.
Main Results:
- Patients with AD exhibited significantly higher median Lp(a) concentrations compared to the control group (152.50 vs. 81.75 mg/L).
- Elevated Lp(a) levels, particularly in the highest quartile, were strongly associated with AD (OR, 8.03; 95% CI, 2.85-22.62).
- This association was consistent across different demographic subgroups, including men and women, and across age groups.
Conclusions:
- Elevated Lipoprotein(a) [Lp(a)] levels represent a significant independent risk factor for aortic dissection (AD).
- These findings underscore the potential role of Lp(a) as a biomarker for identifying individuals at higher risk of AD.
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