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Claudin-18 expression in small bowel adenocarcinoma: a clinico-pathologic study
Giovanni Arpa1,2, Matteo Fassan3,4, Camilla Guerini1,2
1Department of Molecular Medicine, Unit of Anatomic Pathology, University of Pavia, Via Carlo Forlanini 16-27100, Pavia, Italy.
Virchows Archiv : an International Journal of Pathology
|August 4, 2022
Summary
Claudin-18 expression was found in 28% of small bowel adenocarcinomas. This suggests claudin-18 targeted therapy may be a future treatment option for these rare gastrointestinal cancers.
Area of Science:
- Oncology
- Gastroenterology
- Molecular Pathology
Background:
- Non-ampullary small bowel adenocarcinoma is a rare cancer with poor prognosis.
- Claudin 18.2 is a emerging pan-cancer therapeutic target in gastrointestinal malignancies.
Purpose of the Study:
- To investigate claudin-18 expression in small bowel adenocarcinomas.
- To correlate claudin-18 expression with clinico-pathologic features and survival.
- To explore the potential of claudin-18 as a therapeutic target in this cancer type.
Main Methods:
- Immunohistochemistry using clone 43-14A to assess claudin-18 expression in 81 small bowel adenocarcinomas.
- Correlation analysis with clinico-pathologic features (CK7, MUC5AC, CDX2) and patient survival.
Main Results:
- Claudin-18 immunoreactivity was detected in 28% of tumors (≥1% intensity).
- Claudin-18 expression was positively associated with CK7 and MUC5AC, and negatively with CDX2.
- A non-significant trend towards worse survival was observed in claudin-18 positive cases.
Conclusions:
- A subset of small bowel adenocarcinomas, particularly sporadic and Crohn's disease-associated ones with a non-intestinal immunophenotype, express claudin-18.
- Claudin-18 targeted therapy warrants further investigation for these specific cancers.
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