Related Experiment Videos
[Acute diffuse lymphocytic meningoencephalitis: a clinico-pathological report of a case]
Abstract:
A clinicopathologic case of acute diffuse lymphocytic meningoencephalitis in a 8-year-old child is reported. Clinical picture started 7 days prior to death and was characterized by fever and occipital cephalea followed by worsening of general conditions, vomiting and generalized convulsive crisis together with cardiopulmonary arrest and coma. The pathologic examination showed alterations only in the brain, namely pronounced cerebral edema and inflammatory infiltrate, predominantly lymphocytic, perivascular, particularly in the white matter, in all regions analyzed. This case is compared to the ones described in the literature and the etiopathogenesis of acute diffuse lymphocytic meningoencephalitis is discussed. The necessity of making public cases of non-bacterial acute encephalitis is emphasized, due to the fact that most of them remain with undetermined etiology.
Insights
A rare case of acute diffuse lymphocytic meningoencephalitis in a child presented with severe neurological symptoms and brain inflammation. Further research is needed to determine the causes of non-bacterial acute encephalitis.
Area of Science:
- Neuropathology
- Pediatric Neurology
Background:
- Acute diffuse lymphocytic meningoencephalitis is a rare and severe neurological condition.
- Understanding its etiopathogenesis is crucial for diagnosis and treatment.
Observation:
- A clinicopathologic case of an 8-year-old child with acute diffuse lymphocytic meningoencephalitis is presented.
- The child exhibited fever, headache, vomiting, seizures, cardiopulmonary arrest, and coma prior to death.
- Autopsy revealed cerebral edema and perivascular lymphocytic inflammatory infiltrates in the brain's white matter.
Findings:
- The case highlights the characteristic neuropathologic findings of this rare encephalitis.
- Comparison with existing literature aids in understanding the disease spectrum.
Implications:
- Emphasizes the need for reporting non-bacterial acute encephalitis cases to improve etiological understanding.
- Highlights the diagnostic challenges and the importance of neuropathologic examination in such cases.