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Updated: Sep 2, 2025
Micropatterning and Assembly of 3D Microvessels
Published on: September 9, 2016
High endothelial venules as potential gateways for therapeutics
Bilal Hussain1, Vivek Kasinath1, Gabriel P Ashton-Rickardt2
1Transplantation Research Center and Division of Renal Medicine, Brigham and Women's Hospital, Boston, MA, USA.
High endothelial venules (HEVs) are specialized vessels crucial for immune cell entry. Targeting HEVs offers a promising strategy for enhancing cancer immunotherapy and treating immune-mediated diseases.
Area of Science:
- Immunology
- Vascular Biology
- Oncology
Background:
- High endothelial venules (HEVs) facilitate lymphocyte trafficking to lymph nodes.
- Ectopic HEV formation occurs in chronic inflammation and cancer.
- Immunotherapy is revolutionizing cancer treatment.
Purpose of the Study:
- To review the characteristics and formation of HEVs.
- To explore the role of HEVs in immunotherapy and T cell homing to tumors.
- To discuss HEV-targeted therapies for cancer and immune diseases.
Main Methods:
- Literature review of HEV microanatomy, biochemistry, and formation.
- Analysis of HEV's role in T cell homing and immunotherapy.
- Discussion of potential therapeutic strategies targeting HEVs.
Main Results:
- HEVs possess unique microanatomical and biochemical features.
- HEV formation is a dynamic process influenced by inflammatory signals.
- HEV-mediated T cell homing is critical for effective anti-tumor immunity.
Conclusions:
- HEVs are key regulators of immune cell infiltration in health and disease.
- Targeting HEVs can enhance the efficacy of cancer immunotherapies.
- HEV-directed therapies hold potential for treating cancer and immune-mediated disorders.
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