Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Channel Rhodopsins

Channel Rhodopsins

Most organisms use photoreceptors to sense and respond to light. Examples of photoreceptors include bacteriorhodopsins and bacteriophytochromes in some bacteria, phytochromes in plants, and rhodopsins in the photoreceptor cells of the vertebral retina. The light-sensitive property of these receptors is because of the bound chromophores, such as bilin in the phytochromes and retinal in the rhodopsins.
Rhodopsins belong to the family of cell surface proteins called G-protein coupled receptors,...

Gene Therapy

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...

Photoreceptors and Visual Pathways

Photoreceptors and Visual Pathways

At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Non-Erythropoietic EPO (EPO-R76E) Protects RPE Cells from Ferroptosis by Modulating the Labile Iron Pool and NRF2-GPX4 Axis.

Antioxidants (Basel, Switzerland)·2026

Same author

DJ-1 Protects Human Retinal Endothelial Cells From Diabetes-Related Conditions and Prevents Ischemic Damage in Mouse Retinal Capillaries.

Investigative ophthalmology & visual science·2025

Same author

A peptide mimic of SOCS1 modulates equine peripheral immune cells <i>in vitro</i> and ocular effector functions <i>in vivo</i>: implications for recurrent uveitis.

Frontiers in immunology·2025

Same author

Mechanisms of amphibian arrestin 1 self-association and dynamic distribution in retinal photoreceptors.

The Journal of biological chemistry·2024

Same author

Buspirone Enhances Cell Survival and Preserves Structural Integrity during Oxidative Injury to the Retinal Pigment Epithelium.

Antioxidants (Basel, Switzerland)·2023

Same author

Modulation of Retinal Inflammation Delays Degeneration in a Mouse Model of Geographic Atrophy.

bioRxiv : the preprint server for biology·2023

Same journal

The Biology of Malaria Parasite Liver Infection.

Cold Spring Harbor perspectives in medicine·2026

Same journal

The Interaction between Diabetes Mellitus and Tuberculosis: Epidemiology, Screening, and Clinical Management.

Cold Spring Harbor perspectives in medicine·2026

Same journal

New Malaria Prevention Modalities: Long-Acting Interventions Beyond Vaccines.

Cold Spring Harbor perspectives in medicine·2026

Same journal

From Parasite to Pill: Harnessing Biology for Breakthroughs in Antimalarial Drug Discovery.

Cold Spring Harbor perspectives in medicine·2026

Same journal

Malaria Parasite Genomics: Decentralization, Diversification, and Development Goals.

Cold Spring Harbor perspectives in medicine·2026

Same journal

Tuberculosis Infection: Diagnosis and Management.

Cold Spring Harbor perspectives in medicine·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Sep 2, 2025

A Rhodopsin Transport Assay by High-Content Imaging Analysis

A Rhodopsin Transport Assay by High-Content Imaging Analysis

Published on: January 16, 2019

Gene Therapy for Rhodopsin Mutations.

Alfred S Lewin¹, W Clay Smith¹

¹Departments of Molecular Genetics and Microbiology and Ophthalmology, University of Florida College of Medicine, Gainesville, Florida 32610, USA.

Cold Spring Harbor Perspectives in Medicine

|August 8, 2022

Summary

This summary is machine-generated.

Mutations in the rhodopsin gene cause autosomal-dominant retinitis pigmentosa (adRP). Gene therapies show promise for treating adRP by targeting the mutation or preserving photoreceptor cells.

More Related Videos

Limbal Approach-Subretinal Injection of Viral Vectors for Gene Therapy in Mice Retinal Pigment Epithelium

Limbal Approach-Subretinal Injection of Viral Vectors for Gene Therapy in Mice Retinal Pigment Epithelium

Published on: August 7, 2015

Author Spotlight: Advancing Vision Restoration - Stem Cell-Based Therapy for Retinal Diseases

Author Spotlight: Advancing Vision Restoration - Stem Cell-Based Therapy for Retinal Diseases

Published on: October 6, 2023

Related Experiment Videos

Last Updated: Sep 2, 2025

A Rhodopsin Transport Assay by High-Content Imaging Analysis

A Rhodopsin Transport Assay by High-Content Imaging Analysis

Published on: January 16, 2019

Limbal Approach-Subretinal Injection of Viral Vectors for Gene Therapy in Mice Retinal Pigment Epithelium

Limbal Approach-Subretinal Injection of Viral Vectors for Gene Therapy in Mice Retinal Pigment Epithelium

Published on: August 7, 2015

Author Spotlight: Advancing Vision Restoration - Stem Cell-Based Therapy for Retinal Diseases

Author Spotlight: Advancing Vision Restoration - Stem Cell-Based Therapy for Retinal Diseases

Published on: October 6, 2023

Area of Science:

Ophthalmology
Genetics
Molecular Biology

Background:

Mutations in the rhodopsin gene (RHO) are a primary cause of autosomal-dominant retinitis pigmentosa (adRP).
adRP presents with two main clinical phenotypes: early-onset, pan-retinal degeneration, and slowly progressive disease.

Purpose of the Study:

To explore therapeutic strategies for RHO-adRP, including gene-level correction and photoreceptor preservation.
To differentiate treatment approaches based on clinical presentation and disease progression.

Main Methods:

Review of current and emerging gene therapy approaches targeting the RHO gene at DNA or RNA levels.
Evaluation of strategies aimed at sustaining photoreceptor viability independent of mutation correction.

Main Results:

Gene correction and mutant RNA replacement show promise in preclinical models.
Photoreceptor-supportive therapies may delay central vision loss and preserve photoreceptors for future gene-directed treatments.

Conclusions:

Therapeutic strategies for RHO-adRP should be tailored to clinical phenotypes.
Both direct genetic correction and photoreceptor preservation offer potential avenues for treating this inherited retinal disease.