Long-Term Cancer Recurrence Rates following Nipple-Sparing Mastectomy: A 10-Year Follow-Up Study

Area of Science:

• Oncology
• Surgical Oncology
• Breast Surgery

Background:

• Nipple-sparing mastectomy (NSM) is increasingly used for breast cancer treatment.
• Limited data exist on long-term cancer recurrence rates following NSM.

Purpose of the Study:

• To analyze breast cancer recurrence rates in patients who underwent therapeutic NSM.
• To identify potential risk factors for locoregional recurrence after NSM.

Main Methods:

• Retrospective review of 126 therapeutic NSMs performed on 120 patients.
• Median follow-up of 10 years.
• Analysis of demographic factors, pathology findings, and oncologic outcomes; univariate analysis for risk factors.

Main Results:

• The overall recurrence rate was 3.17% per mastectomy and 3.33% per patient.
• Common histologies included invasive ductal carcinoma and ductal carcinoma in situ.
• No demographic, operative, or tumor-specific variables were independent risk factors for recurrence.

Conclusions:

• Therapeutic NSM demonstrates low long-term breast cancer recurrence rates.
• Close surveillance is crucial for early detection of recurrence in NSM patients.