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Related Concept Videos

Organic Compounds03:02

Organic Compounds

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All living things are formed mostly of carbon compounds called organic compounds. The category of organic compounds includes both natural and synthetic compounds that contain carbon. Although a single, precise definition has yet to be identified by the chemistry community, most agree that a defining trait of organic molecules is the presence of carbon as the principal element, bonded to hydrogen and other carbon atoms. However, some carbon-containing compounds such as carbonates, cyanides, and...
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Organic chemistry is the study of compounds of carbon called organic compounds. Organic compounds either originate from living organisms or are synthesized by chemists. A defining trait of these compounds is the presence of carbon as the principal element, which is bonded to other carbon atoms and other elements such as hydrogen, oxygen, nitrogen, and sulfur. The existence of a wide array of organic molecules is a consequence of carbon atoms’ ability to form up to four strong bonds to...
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Aromatic Compounds: Overview01:25

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In general, the term ‘aromatic’ indicates a pleasant smell or fragrance from fresh flowers, freshly prepared coffee, etc. In the early history of organic chemistry, many benzene derivatives were isolated from the pleasant odor oils of the plants. For example, vanillin was isolated from the oil of vanilla, methyl salicylate from the oil of wintergreen, and cinnamaldehyde from the oil of cinnamon. They all had a pleasant odor; hence the name aromatic was given.
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Chemical factors such as changing CO2, O2, and H+ levels in arterial blood play a critical role in influencing respiration depth and rates. These variations are detected by chemoreceptors—specialized sensors located in two primary body areas. Central chemoreceptors are found throughout the brain stem, including the ventrolateral medulla, while peripheral chemoreceptors are located in the aortic arch and carotid arteries.
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Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
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Serum Laboratory Studies, Stool Test, Breath Test01:30

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Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
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Breath Collection from Children for Disease Biomarker Discovery
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Volatile Organic Compounds in Human Breath.

Monika Karunagaran1, Pratibha Ramani1, S Gheena1

  • 1Department of Oral Pathology and Microbiology, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Science, Saveetha University, Chennai, Tamil Nadu, India.

Indian Journal of Dental Research : Official Publication of Indian Society for Dental Research
|August 10, 2022
PubMed
Summary
This summary is machine-generated.

Breathomics analyzes volatile organic compounds (VOCs) in exhaled breath for non-invasive disease diagnosis. This approach offers a promising tool for observing biochemical processes and identifying potential disease biomarkers.

Keywords:
Breath analysisGC-MSVOCs

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Area of Science:

  • Biochemistry
  • Analytical Chemistry
  • Medical Diagnostics

Background:

  • Exhaled breath contains a complex mixture of volatile organic compounds (VOCs) and other molecules.
  • These VOCs originate from various physiological and pathophysiological conditions within the body.
  • Analyzing these compounds offers a non-invasive window into the body's biochemical status.

Purpose of the Study:

  • To introduce and define breathomics as a comprehensive analysis of VOCs in exhaled breath.
  • To highlight the potential of breathomics as a non-invasive diagnostic tool for various diseases.
  • To establish VOCs in breath as potential biomarkers for disease detection.

Main Methods:

  • Comprehensive analysis of volatile organic compounds (VOCs).
  • Utilizing exhaled breath samples for analysis.
  • Focusing on the identification and quantification of VOCs.

Main Results:

  • Breath samples are identified as complex mixtures of VOCs and other molecules.
  • The analysis of total VOCs in exhaled breath shows promise for disease diagnosis.
  • VOCs are confirmed to be produced under diverse physiological and pathophysiological conditions.

Conclusions:

  • Breathomics is a valuable non-invasive approach for disease diagnosis.
  • VOCs in exhaled breath serve as potential biomarkers for a range of diseases.
  • Further research in breathomics can significantly advance diagnostic capabilities.