Cysteine and related aminothiols in cardiovascular disease, obesity and insulin resistance
Related Experiment Video
Updated: Sep 1, 2025

Resin-Assisted Capture Coupled with Isobaric Tandem Mass Tag Labeling for Multiplexed Quantification of Protein Thiol Oxidation
Published on: June 21, 2021
Maria Leonor Pavão1, Rita Ferin1, Ana Lima1
1FCT, University of the Azores, Ponta Delgada, Portugal.
Abstract:
Cysteine, homocysteine, glutathione and cysteinylglycine are metabolically related low molecular weight aminothiols involved in antioxidant defense and in thiol redox control in many cellular and extracellular processes. Alterations in plasma aminothiol profiles are evident in pathologic conditions associated with oxidative stress and accordingly can be considered potential biomarkers. More recently, cysteine has received special attention on this regard and several methodologies for the separation and measurement of cysteine as well as other related aminothiols have been developed and refined. In this review, we provide insight into characteristics, biologic functions, and metabolic interactions of aminothiols (including their involvement in thiol redox status). We highlight cysteine and review methodologic approaches to elucidate its potential role as a risk factor as well as a biomarker in cardiovascular disease, obesity and insulin resistance.
Related Concept Videos
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
Coronary Artery Disease I: Introduction
Transducer Mechanism: Enzyme-Linked Receptors
Major types that are helpful drug targets include:
Atherosclerosis III: Management
Cystic Fibrosis: Pathogenesis
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
Sulfur Assimilation

