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High Spatial Resolution Chemical Imaging of Implant-Associated Infections with X-ray Excited Luminescence Chemical Imaging Through Tissue

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Direct Conversion X-ray Detector with Micron-Scale Pixel Pitch for Edge-Illumination and Propagation-Based X-ray

Abdollah Pil-Ali^1,2, Sahar Adnani^1,2, Christopher C Scott³

¹Department of Electrical and Computer Engineering, University of Waterloo, 200 University Ave W, Waterloo, ON N2L 3G1, Canada.

Sensors (Basel, Switzerland)

|August 12, 2022

Summary

This study explored high-resolution direct conversion X-ray detectors for phase-contrast imaging. Edge illumination X-ray phase-contrast imaging (EI-XPCi) showed superior performance, but requires careful mask quality control.

Keywords:

X-ray phase-contrast imaging amorphous selenium coded-aperture direct conversion detector edge-illumination high-resolution imaging micron-scale pixel detector propagation-based

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Area of Science:

Medical Imaging
Physics
Materials Science

Background:

X-ray phase-contrast imaging (XPCi) offers enhanced sensitivity over conventional radiography.
Direct conversion X-ray detectors with micron-scale pixels are emerging for advanced imaging.

Purpose of the Study:

To evaluate the performance of direct conversion detectors in two XPCi configurations: propagation-based (PB-XPCi) and edge illumination (EI-XPCi).
To compare PB-XPCi and EI-XPCi using a wave optics model for contrast, edge-enhancement, visibility, and dose efficiency.

Main Methods:

Numerical simulation using a wave optics model in MATLAB.
Evaluation of PB-XPCi and EI-XPCi configurations with micron-scale pixel detectors.
Analysis of contrast, edge-enhancement, visibility, and dose efficiency.

Main Results:

EI-XPCi generally outperformed PB-XPCi in terms of imaging performance.
Challenges for EI-XPCi include absorption mask quality and environmental vibrations.
High-resolution EI-XPCi system performance is sensitive to absorption mask thickness and alignment.

Conclusions:

Direct conversion detectors with micron-scale pixels are feasible for XPCi.
EI-XPCi offers potential for higher dose efficiency, contrast, and compact systems.
Further research is needed to address challenges in EI-XPCi mask fabrication and stability.