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Giant cell myocarditis following COVID-19 successfully treated by immunosuppressive therapy

Afsaneh Amiri1, Golnaz Houshmand1, Sepideh Taghavi1

  • 1Rajaie Cardiovascular Medical and Research Center School of medicine, Iran University of Medical Sciences Tehran Iran.

Clinical Case Reports
|August 12, 2022
PubMed

Insights

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause heart failure. This case report details a patient successfully treated for COVID-19-related heart failure with immunosuppressive therapy.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Immunology

Background:

  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, causing coronavirus disease 2019 (COVID-19), is linked to multi-organ impairment, including cardiac and immunological complications.
  • Acute myocarditis is a recognized severe complication of COVID-19.

Observation:

  • A 46-year-old female with a history of lichen planus dermatitis experienced rapidly progressive heart failure following a COVID-19 infection.
  • Endomyocardial biopsy results were consistent with giant cell myocarditis (GCM).

Findings:

  • The patient's heart failure was diagnosed as GCM post-COVID-19.
  • Successful treatment was achieved using a combination immunosuppressive therapy regimen.

Implications:

  • This case highlights a rare but serious cardiac complication of COVID-19.
  • Immunosuppressive therapy may be an effective treatment for GCM in the context of COVID-19.
  • Further research into the immunological mechanisms of COVID-19-induced myocarditis is warranted.

Keywords:
COVID‐19Giant cellmyocarditis

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