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Adoptive B cell therapy for chronic viral infection
Young Rock Chung1, Tanushree Dangi1, Nicole Palacio1
1Department of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL, United States.
Adoptive B cell therapy shows promise for chronic infections by increasing antibody levels and reducing viral loads. Optimal effectiveness, however, may require virus-specific CD4 T cells for enhanced viral neutralization.
Area of Science:
- Immunology
- Virology
- Infectious Diseases
Background:
- T cell-based therapies are established for cancer and chronic infections.
- B cell-based therapies remain under-explored for treating chronic infections.
Purpose of the Study:
- To investigate the efficacy of adoptive B cell therapy in a chronic viral infection model.
- To determine the role of B cell antibody effector functions and CD4 T cells in therapy success.
Main Methods:
- Adoptive transfer of virus-specific B cells into mice with chronic lymphocytic choriomeningitis virus (LCMV) infection.
- Assessment of antibody titers, viral loads, and the impact of co-transferred virus-specific CD4 T cells.
Main Results:
- Adoptive B cell transfer increased antibody titers and reduced viral loads.
- Therapeutic efficacy was partly dependent on antibody effector functions.
- Co-transferring virus-specific CD4 T cells improved B cell therapy outcomes.
Conclusions:
- Adoptive B cell therapy offers a potential strategy for treating chronic viral infections.
- Virus-specific CD4 T cells are critical for optimizing B cell therapy and viral neutralization.
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