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Updated: Sep 1, 2025
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Published on: August 6, 2019
Matrix metalloproteinase-9-1562 C/T promoter gene polymorphism in chronic periodontitis: A cross-sectional
Puja Sarkar1, Thamil Selvan Muthuraj2, Prasanta Bandyopadhyay3
1Dental Department, North Bengal Medical College and Hospital, Siliguri, West Bengal, India.
Background:
Matrix metalloproteinases (MMPs) are a major group of enzymes, released in inflamed periodontal tissues in large quantities, resulting in connective tissue matrix breakdown. One of the most predominant MMPs is MMP-9. Association between chronic periodontitis (CP) and MMP-9 gene polymorphism (GP) in some ethnic populations has been already established. The aim of the current study was to assess the association of single-nucleotide polymorphism in the promoter region of MMP-9 gene with CP in Kolkata population, if any.
Materials And Methods:
Forty eligible individuals were recruited for the study and grouped as A and B: Group A (twenty periodontally healthy individuals) and Group B (twenty CP patients). Venous blood samples collected from all the forty individuals were used to isolate the genomic DNA. GP for MMP-9 gene was detected using polymerase chain reaction and sequencing method. The data obtained were then analyzed statistically.
Results:
A significantly different genotypic and allelic variation was observed in the control and test groups, with C/T genotype and T allele present in only CP group.
Conclusion:
Within the limitations of this study, we can conclude that there was no significant association between patients with periodontitis and MMP-9-1562 C/T promoter GP.
