RELATIONSHIP BETWEEN SARCOPENIA AND OSTEOPOROSIS IN NON-ALCOHOLIC FATTY LIVER DISEASE

The article analyzes the scientific literature on the mechanisms of interaction of bones, muscles and adipose tissue in non-alcoholic fatty liver disease. Modern views on the mechanisms of sarcopenia, osteopenia and osteoporosis are highlighted. Interactions between muscles and bones involve the interaction of osteokines released from bones, muscle myokines, and cytokines, which trigger common signaling pathways leading to fibrosis, inflammation, or protein synthesis or degradation. The pathogenetic link between sarcopenia, osteoporosis and non-alcoholic fatty liver disease has been established. Numerous studies convincingly 17 suggest that abdominal obesity, hypertension, dyslipidemia and dysglycemia are considered components of the metabolic syndrome and are closely related to osteoporosis. Methods of prevention and treatment of sarcopenia and osteoporosis have been clarified. It has been suggested that dynamic resistance exercises, supported by adequate nutritional therapy, may be the most promising strategy for improving the clinical condition of elderly patients with osteosarcopenia with beneficial metabolic effects and positive effects on the nervous and cardiovascular systems. Thus, direct relationships have been established between adipose and muscle tissue and bone mineral density. Fatty infiltration of muscles not only leads to loss of muscle mass and strength, but also contributes to insulin resistance, non-alcoholic fatty liver disease. Oxidative stress and chronic inflammation cause muscle atrophy and lead to stress responses in hepatocytes, leading to the progression of liver fibrosis. Exercise with exercise significantly reduces the loss of bone and muscle mass.