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GENETIC INFLUENCES ON PAIN MECHANISMS
Yaroslav Semkovych1, Dmytro Dmytriiev2
1IVANO-FRANKIVSK NATIONAL MEDICAL UNIVERSITY, IVANO-FRANKIVSK, UKRAINE.
Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|August 13, 2022
Summary
Genetic factors significantly influence pain syndrome development. Understanding gene-environment interactions is crucial for diagnosing and predicting pain, especially in children.
Area of Science:
- Genetics and Pain Research
- Molecular Biology and Medicine
Background:
- Pain is a complex human experience influenced by multiple factors.
- Genetic predispositions play a role in the development of pain syndromes.
Purpose of the Study:
- To review existing research on genetic influences in pain syndrome development.
- To synthesize findings on genetic mechanisms affecting pain perception and chronicity.
Main Methods:
- Systematic review of 45 research papers published between 2009 and 2020.
- Inclusion of studies in English and Ukrainian from major databases (PubMed, EMBASE, Cochrane, Google Scholar).
- Focus on genetic influences on pain mechanisms in adults and children.
Main Results:
- Multiple genes with small individual effects interact with environmental factors.
- These interactions influence susceptibility to pain and the manifestation of chronic pain syndromes.
- Genetic contributions to pain are complex and multifactorial.
Conclusions:
- Pain is a comprehensive trait influenced by intricate genetic and environmental interactions.
- Identifying genetic biomarkers is essential for diagnosing and predicting acute and chronic pain.
- Special attention is needed for pediatric pain syndrome development and genetic understanding.
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