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Pathophysiology of Asthma-Chronic Obstructive Pulmonary Disease Overlap
Andi Hudler1, Fernando Holguin1, Sunita Sharma1
1Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Anschutz Medical Campus, 12700 East 19th Avenue, 9C03, Aurora, CO 80045, USA.
Abstract:
Asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) is a condition in which a person has clinical and biological features of both asthma and COPD. The pathophysiology behind the development of ACO is complex, with various inflammatory cells, cytokines, environmental factors, and architectural changes within the airways, all affecting a patient's clinical manifestation. A better understanding of the pathophysiologic mechanisms resulting in the development of ACO will help us to better identify potential drug targets and improve symptom burden and overall quality of life for patients living with ACO.
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