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Updated: Aug 6, 2026
A Reversible Silicon Oil-Induced Ocular Hypertension Model in Mice
Published on: November 15, 2019
Foreign body giant cell reaction to silicone oil presenting as a salmon-patch conjunctival lesion
Corrina P Azarcon1, Hans E Grossniklaus1, Jill R Wells1
1Ocular Oncology and Pathology Section, Emory Eye Center, Emory University School of Medicine, Atlanta, GA, USA.
Purpose:
To describe a case of foreign body giant cell reaction to silicone oil that presented as a salmon-patch conjunctival lesion.
Observations:
An elderly female with prior retinal surgery and oil tamponade was referred for a salmon-patch lesion in the conjunctiva. Biopsy revealed multiple vacuolations and foreign body giant cells in the substantia propria, consistent with a foreign body reaction to silicone oil.
Conclusion And Importance:
Silicone oil can elicit an inflammatory reaction in the conjunctiva that could mimic a neoplasm. Excessive leakage of oil into the subconjunctival space should be avoided to prevent this complication.
