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Updated: Sep 1, 2025
11:22
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
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Interaction between microbiota and immunity and its implication in colorectal cancer
Changsheng Xing1, Yang Du1, Tianhao Duan1
1Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
Frontiers in Immunology
|August 15, 2022
Summary
Colorectal cancer (CRC) risk is linked to gut inflammation and the microbiome. Understanding how gut bacteria interact with immunity can lead to new therapies for colitis and CRC.
Area of Science:
- Gastroenterology
- Oncology
- Immunology
Background:
- Colorectal cancer (CRC) is a leading cause of cancer death globally.
- Colonic inflammation, influenced by genetics, immune cells, cytokines, and microbiota, is a major CRC risk factor.
- The interplay between CRC and the gut microbiome is a critical research focus.
Purpose of the Study:
- To review the interactions between gut microbiota and host immunity in CRC development.
- To explore how this crosstalk regulates inflammation and CRC.
- To highlight microbiota's potential in developing novel therapeutic strategies.
Main Methods:
- Review of current literature on CRC, gut microbiome, and host immunity.
- Analysis of metagenomic profiling studies identifying CRC-associated bacteria.
- Examination of mechanistic studies on microbiota-mediated immune signaling pathways.
Main Results:
- Metagenomic studies reveal specific bacterial species enriched in CRC patients, correlating with colitis and cancer.
- Certain gut microbes promote CRC development, while others elicit protective immunity.
- Microbiota influences immune cell activation and inflammation via pathways like NF-κB and inflammasome signaling.
Conclusions:
- Gut microbiota and host immunity crosstalk significantly impacts inflammation and CRC pathogenesis.
- Targeting these interactions offers potential for microbiota-based therapies to prevent or treat colitis and CRC.
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