Sex differences in decision-making: Identifying multisensory behavioral differences in males and hermaphrodites

This present study uses C. elegans as a model to investigate how sex differences can influence sensory behavior and decision-making when encountering conflicting cues. We use a multi-sensory behavioral assay to characterize the differences between hermaphrodites and male worms when escaping from a food lawn during exposure to repulsive odors, such as, 2-nonanone. We find that male worms show a delayed food leaving during exposure to 2-nonanone when compared to hermaphrodite worms, and this is observed across multiple repulsive cues (2-nonanone and undiluted benzaldehyde) and multiple food types ( E. coli (OP50) and Comamonas sp ). Overall, this study provides a platform to further investigate how sensory-dependent decision-making behavior differs between sexes.