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Diagnostic plasmonic sensors: opportunities and challenges.
Chandreyee Manas Das1,2, Kien Voon Kong3, Ken-Tye Yong4,5,6
1School of Electrical and Electronic Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore.
Chemical Communications (Cambridge, England)
|August 17, 2022
Summary
Advanced plasmonic sensing offers rapid and accurate detection of disease biomarkers, revolutionizing medical diagnostics for inflammatory, metabolic, and cardiovascular conditions. This technology aids timely intervention and therapy, improving patient quality of life.
Area of Science:
- Biomedical Engineering
- Nanotechnology
- Medical Diagnostics
Background:
- Healthcare systems face significant strain from prevalent inflammatory, metabolic, and cardiovascular diseases.
- Advanced sensing technologies are crucial for improving patient quality of life and managing disease burden.
- Plasmonic resonance effects offer enhanced capabilities for rapid and accurate biological marker detection.
Purpose of the Study:
- To review the fundamentals and development of plasmonic sensing technology.
- To highlight the sensitivity of Surface Plasmon Resonance (SPR) and Localized Surface Plasmon Resonance (LSPR) sensors.
- To discuss the chemistry involved in functionalizing plasmonic sensors for medical applications.
Main Methods:
- Review of existing literature on plasmonic sensing fundamentals and applications.
- Analysis of sensitivity data for various SPR and LSPR sensor configurations.
- Discussion of surface chemistry strategies for sensor functionalization.
Main Results:
- Plasmonic sensing has significantly advanced medical diagnostics, enabling faster and more accurate disease detection.
- SPR and LSPR sensors demonstrate high sensitivity in detecting biological markers.
- Functionalization chemistry is key to tailoring plasmonic sensors for specific diagnostic targets.
Conclusions:
- Plasmonic sensing technology is revolutionizing medical diagnostics by enabling rapid and accurate detection of disease biomarkers.
- The review underscores the potential of plasmonic sensors to improve patient outcomes through timely intervention and therapy support.
- Future directions in plasmonic sensor development are suggested to further enhance diagnostic capabilities.
