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Microfluidic Applications for Disposable Diagnostics
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Microfluidic systems in clinical diagnosis.

Blanca H Lapizco-Encinas1, Yan Victoria Zhang2

  • 1Microscale Bioseparations Laboratory and Biomedical Engineering Department, Rochester Institute of Technology, Rochester, New York, USA.

Electrophoresis
|August 17, 2022
PubMed
Summary
This summary is machine-generated.

Microfluidic devices offer portable and rapid clinical assessments for ions, sugars, and proteins. This review highlights advancements in wearable sensors and single-cell analysis for improved patient diagnostics.

Keywords:
biomedical analysisclinical diagnosislaboratory medicinemicrofluidicsminiaturization

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Area of Science:

  • Biomedical Engineering
  • Clinical Diagnostics
  • Analytical Chemistry

Background:

  • Microfluidic devices are increasingly vital for biomedical and clinical assessments due to their portability and speed.
  • The demand for rapid, point-of-care diagnostic tools is growing, driving innovation in microfluidics.
  • Miniaturized systems offer significant advantages for analyzing biological samples efficiently.

Purpose of the Study:

  • To review recent advancements in microfluidic devices for clinical applications.
  • To explore the use of microfluidics in quantifying ions, sugars, metabolites, and proteins.
  • To discuss the development of devices for single-cell metabolomic and proteomic analysis.

Main Methods:

  • Review of recent scientific literature (last 5 years) on microfluidic devices for clinical use.
  • Categorization of devices based on analytes: ions/sugars/metabolites, proteins, and single-cell analysis.
  • Evaluation of device maturity, cost-effectiveness, and novel contributions.

Main Results:

  • Microfluidics are successfully applied in quantifying key biomarkers from bodily fluids.
  • Wearable real-time devices for analyte quantification show increasing maturity and cost-effectiveness.
  • Devices for single-cell metabolomic and proteomic assessments represent a significant frontier.

Conclusions:

  • Microfluidic technology is rapidly evolving for diverse clinical diagnostic applications.
  • Recent innovations focus on enhanced sensitivity, portability, and multiplexed analysis.
  • Future directions include further integration into point-of-care settings and advanced single-cell studies.