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Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
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Pediatric Chronic Kidney Disease

Valerie Panzarino1, Jake Lesser2, Frank Ayestaran Cassani1

  • 1Department of Pediatrics, Division of Pediatric Nephrology, University of South Florida Health, 2 Tampa General Circle, Fifth Floor, Tampa, FL 33606, USA.

Advances in Pediatrics
|August 19, 2022
PubMed

Insights

Pediatric chronic kidney disease (CKD) requires accurate staging and monitoring for complications. Management involves treating the cause and using protective measures, ideally with a multidisciplinary team.

Area of Science:

  • Pediatric Nephrology
  • Renal Medicine
  • Child Health

Background:

  • Chronic kidney disease (CKD) in children significantly affects health outcomes and quality of life.
  • Accurate assessment of renal dysfunction is crucial for effective management.

Purpose of the Study:

  • To outline the importance of staging pediatric CKD using specific formulas.
  • To highlight key comorbidities and management strategies for pediatric CKD.
  • To emphasize the need for a multidisciplinary approach in managing pediatric CKD.

Main Methods:

  • Utilizing pediatric-specific formulas to calculate the degree of renal dysfunction.
  • Staging CKD to guide treatment and monitoring.
  • Identifying and managing comorbid conditions associated with pediatric CKD.

Main Results:

  • Accurate staging facilitates appropriate medication dosing.
  • Monitoring for complications like metabolic acidosis, bone disease, anemia, cardiovascular issues, malnutrition, electrolyte imbalances, growth failure, and psychosocial problems is essential.
  • Treatment involves addressing the underlying disease and implementing renal protective measures.

Conclusions:

  • Effective management of pediatric CKD necessitates a specialized, multidisciplinary team approach.
  • Early and accurate diagnosis and staging are key to improving outcomes for children with CKD.

Keywords:
Chronic kidney diseaseEnd-stage renal diseasePediatrics

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