Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Epilepsy and Seizures: Overview01:24

Epilepsy and Seizures: Overview

261
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
261
Psychosurgery01:30

Psychosurgery

98
Psychosurgery, the surgical alteration or permanent removal of brain tissue to alleviate severe psychological conditions, stands as one of the most radical and controversial treatments in the history of mental health care. Its development and application have evolved significantly, marked by dramatic shifts in scientific understanding and ethical perspectives.
Historical Development of Psychosurgery
In the 1930s, Portuguese neurologist Antonio Egas Moniz introduced a surgical procedure designed...
98
Antiepileptic Drugs: GABAergic Pathway Potentiators01:18

Antiepileptic Drugs: GABAergic Pathway Potentiators

578
γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
578

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pediatric epilepsy surgery: Global survey of invasive explorations.

Epilepsia·2026
Same author

Use of artificial intelligence in magnetic resonance imaging across the epileptic patient's journey: A meta-analysis of four clinical applications.

Epilepsia·2026
Same author

Pediatric epilepsy surgery: Global survey of referral and presurgical evaluation practices.

Epilepsia·2026
Same author

Developmental profile of physiological high-frequency oscillations in the human brain.

NeuroImage·2026
Same author

H3K27me3 spreading organizes canonical PRC1 chromatin architecture to regulate developmental programs.

Nature genetics·2026
Same author

Real-world outcomes of responsive neurostimulation in patients with Lennox-Gastaut syndrome: A multicenter retrospective study.

Epilepsia open·2026
Same journal

Two Steps Forward-One Step Back: Keeping Pace with Advances.

Advances in pediatrics·2025
Same journal

Pediatric Lymphadenopathy.

Advances in pediatrics·2025
Same journal

Vascular and Gastrointestinal Access in Children.

Advances in pediatrics·2025
Same journal

The Ouchless Pediatric Emergency Department.

Advances in pediatrics·2025
Same journal

Seizures and Shaking in Newborns and Babies.

Advances in pediatrics·2025
Same journal

Procalcitonin in Pediatric Emergency Medicine.

Advances in pediatrics·2025
See all related articles

Related Experiment Video

Updated: Aug 31, 2025

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
11:29

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Published on: August 15, 2025

590

Brain Surgery for Medically Intractable Epilepsy.

Vincent Joris1, Alexander G Weil2, Aria Fallah3

  • 1Fellow, Department of Neurosurgery, Sainte-Justine University Hospital Centre, 3175 Chemin de la Côte-Sainte-Catherine, Montreal, Quebec H3T 1C5, Canada.

Advances in Pediatrics
|August 19, 2022
PubMed
Summary
This summary is machine-generated.

Pediatric intractable epilepsy surgery is reviewed, covering advanced presurgical evaluations and surgical options like lesionectomies and hemispherectomies. The review highlights key differences in treating children versus adults with epilepsy.

Keywords:
Epilepsy surgeryMedically intractable epilepsyOutcomesResectionSurgical selection

More Related Videos

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex
09:00

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex

Published on: April 15, 2015

12.4K
Performing Behavioral Tasks in Subjects with Intracranial Electrodes
12:10

Performing Behavioral Tasks in Subjects with Intracranial Electrodes

Published on: October 2, 2014

11.5K

Related Experiment Videos

Last Updated: Aug 31, 2025

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
11:29

Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study

Published on: August 15, 2025

590
Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex
09:00

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex

Published on: April 15, 2015

12.4K
Performing Behavioral Tasks in Subjects with Intracranial Electrodes
12:10

Performing Behavioral Tasks in Subjects with Intracranial Electrodes

Published on: October 2, 2014

11.5K

Area of Science:

  • Neurosurgery
  • Pediatric Neurology
  • Epileptology

Background:

  • Intractable epilepsy in children poses significant challenges.
  • Surgical intervention is a critical treatment option for refractory cases.
  • Understanding pediatric-specific factors is crucial for successful surgical outcomes.

Purpose of the Study:

  • To provide a comprehensive review of brain surgery for pediatric intractable epilepsy.
  • To detail advancements in presurgical evaluation and diagnostic testing.
  • To outline various surgical techniques and their indications in pediatric epilepsy.

Main Methods:

  • Review of current literature on pediatric epilepsy surgery.
  • Analysis of presurgical workup protocols and diagnostic modalities.
  • Categorization of epilepsy types and surgical procedures.

Main Results:

  • Detailed description of presurgical workup and essential tests.
  • Classification of epilepsy types (temporal, extratemporal, multifocal, hemispheric) from a surgical perspective.
  • Overview of surgical options including lesionectomies, lobectomies, hemispherectomies, neuromodulation, and palliative surgeries.

Conclusions:

  • Brain surgery offers viable treatment options for pediatric intractable epilepsy.
  • Tailored surgical approaches are necessary, considering the unique aspects of pediatric patients.
  • Advancements in presurgical evaluation improve surgical decision-making and outcomes.