In vitro high-content tissue models to address precision medicine challenges

Area of Science:

• Biotechnology
• Regenerative Medicine
• Medical Engineering

Background:

• Precision medicine aims for personalized treatments, improving disease management and reducing costs.
• Current challenges in precision medicine include developing accurate diagnostic and therapeutic tools.
• The COVID-19 pandemic highlighted the urgent need for advanced medical solutions.

Purpose of the Study:

• To explore the integration of organ-on-a-chip and bioprinting technologies for precision medicine.
• To address challenges in disease prevention, diagnosis, and treatment, particularly for pandemics like COVID-19.
• To review technological advancements and future needs for pandemic preparedness and precision medicine.

Main Methods:

• Engineering high-content in vitro tissue models by combining organ-on-a-chip and bioprinting.
• Developing physiologically representative in vitro models tailored to individuals.
• Utilizing these models for rapid screening of therapeutics for efficacy and toxicity.

Main Results:

• The convergence of bioprinting and organ-on-a-chip technologies shows promise for tackling pandemics.
• These integrated technologies can facilitate the development of advanced diagnostics and personalized treatments.
• Individual-specific in vitro models enable faster and more accurate therapeutic evaluation.

Conclusions:

• Organ-on-a-chip and bioprinting are powerful tools for advancing precision medicine.
• These technologies are crucial for addressing current and future pandemic needs.
• Further maturation of these fields is essential for comprehensive pandemic response and personalized healthcare.